Rapisarda et al., Cancer Res 2004
:
In addition, we demonstrate that Top 1 is required for the inhibition of HIF-1alpha protein accumulation by TPT as shown by experiments performed using camptothecin-resistant cell lines with known Top 1 alterations
Choi et al., J Cancer Res Clin Oncol 2009
(Carcinoma, Non-Small-Cell Lung...) :
Both Top I and II inhibitors could suppress the HIF-1alpha expression in a schedule dependent manner, and this suggests that these drugs might be useful to overcome the therapeutic resistance induced by tumor hypoxia in NSCLC