Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
AKT1
→
TNS2
(decreases, TNS2 Activity)
Evidence: Furthermore, serum starvation-induced apoptosis caused a twofold increase in caspase 3 activity in C1-TEN-overexpressing cells vs. mock cells. In addition, C1-TEN-overexpressing cells showed a markedly reduced phosphorylation of Akt/PKB kinase and its substrate GSK3, as well as reduced Akt enzymatic activity. Equal amounts of total cell lysates were subjected to 10% SDSPAGE. The membrane was then probed with polyclonal antibody against GSK3 specifically phosphorylated at Ser21/9 (pGSK3?/?, CST)...