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STAT3 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT3 → TNF (increases)
  Evidence: TNF-alpha-induced IL-6 production was significantly decreased by infection with AxCAdnSTAT3 (adenovirus carrying dominant negative STAT3).

Text-mined interactions from Literome

Riley et al., J Biol Chem 1999 (Inflammation) : Herein, we demonstrate that the ability of IL-10 to inhibit tumor necrosis factor alpha (TNFalpha) production in lipopolysaccharide stimulated macrophages requires the presence of Stat3 , Jak1, and two distinct regions of the IL-10 receptor intracellular domain
Bode et al., FEBS Lett 1999 : LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6 induced activation of STAT3 in macrophages
Miscia et al., Cell Growth Differ 2002 (Lymphoma, B-Cell) : Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells
Bode et al., J Immunol 2003 : Recently, it has been demonstrated that TNF-alpha and LPS induce the expression of suppressor of cytokine signaling 3 ( SOCS3 ) and inhibit IL-6 induced STAT3 activation in macrophages
Williams et al., J Immunol 2004 : Macrophage-specific STAT3-null mice have demonstrated that STAT3 plays a critical role in the suppression of LPS induced TNF-alpha release, although the mechanism by which STAT3 mediates this inhibition is still not clear
Yu et al., J Biol Chem 2004 : This difference seemed to be underlain by differential induction of signal transducers and activators of transcription ( STAT ) activation in that, whereas flagellin and TNFalpha seemed to be equipotent activators of p38 mitogen activated protein kinase and nuclear factor-kappaB, flagellin induced substantially higher levels of STAT-1 and -3 tyrosine phosphorylation
Theiss et al., J Biol Chem 2005 (Fibrosis...) : Differences in TNFalpha induced STAT3/DNA binding activity and not NFkappaB and AP-1 transcriptional activation correlated with impaired collagen accumulation/TIMP-1 induction in TNFR2 ( -/- ) cells
Liu et al., Zhonghua Wai Ke Za Zhi 2006 : STAT1 and STAT3 might be involved in the regulation of TNF-alpha gene expression, but not in TNF-alpha early release ( < 24 hours ) induced by HMGB1 stimulation in rat peritoneal macrophages
Robinson et al., J Am Coll Surg 2006 : Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J ... We hypothesized that tumor necrosis factor (TNF)-alpha would induce STAT1 and STAT3 , and PYY would attenuate their transcription factor binding ... Results from both the electrophoretic mobility shift assay- and the ELISA based assays verified STAT1 and STAT3 responses to TNF-alpha and PYY ... In pancreatic acinar cells, TNF-alpha activated STAT1 and STAT3 , known mediators of inflammatory cytokines
Rigby et al., Oncogene 2007 (Colonic Neoplasms...) : In vitro, SOCS3 overexpression reduced proliferation, IL-6 mediated STAT3 activation and tumor necrosis factor (TNF) alpha mediated NF-kappaB activation
Prêle et al., Clin Exp Immunol 2007 : STAT3 activated by LPS did not directly regulate inhibitor of kappa B alpha ( IkappaBalpha ) activation or tumour necrosis factor (TNF)-alpha production, a process dependent on the transcriptional activity of nuclear factor kappa B (NFkappaB), although the transcriptional activity of STAT3 contributed to the mechanism by which interleukin (IL)-10 suppressed LPS induced TNF-alpha levels ... These results indicate that STAT3 activation can not directly regulate LPS signalling in human monocytes and represents only part of the mechanism by which IL-10 suppresses TNF-alpha production by activated human monocytes
Sudo et al., Biochim Biophys Acta 2008 : In conclusion, The TNF-alpha and IL-6 signals from the blood are necessary for liver regeneration and NF-kappaB and STAT3 binding are activated via TNF-alpha and IL-6 signal pathways
Samavati et al., Mol Immunol 2009 (Inflammation) : A newly developed STAT3 specific inhibitor ( stattic ) blocked LPS mediated STAT3 tyrosine phosphorylation and led to inhibition of LPS mediated IL-1beta and IL-6 production but not TNF-alpha production
Hao et al., Int J Radiat Biol 2010 : P6, a JAK inhibitor, reduced induction of iNOS and TNF-alpha , nuclear factor binding activity, and activation of STAT3 in EMF stimulated microglia
Tanabe et al., Journal of neuroinflammation 2010 (Glioma) : TNF-alpha induced phosphorylation of STAT3 ... The Janus family of tyrosine kinase ( JAK ) inhibitor I, an inhibitor of JAK 1, 2 and 3, attenuated TNF-alpha induced phosphorylation of STAT3 and significantly reduced TNF-alpha stimulated IL-6 release
Luo et al., Mol Cell Biochem 2012 : Administration of the ROS scavenger catalase ( 2,000 U/ml ) remarkably inhibited TNF-a induced cell proliferation and STAT3 activation
de Jong et al., PloS one 2012 (Inflammation) : STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass ... Our findings suggest that STAT3 signaling plays a crucial role in the downregulation of TNF-a synthesis by human monocytes in the course of systemic inflammation in vivo
Lee et al., J Nutr Biochem 2013 (Pneumonia) : In addition, EGCG also attenuated TNF-a induced oxidative stress, p47(phox) translocation, MAPKs activation, and STAT-3 and activating transcription factor (ATF)2 phosphorylation
Gan et al., Endocrinology 2012 : TNF-a also acutely increased LEPRb cell surface expression and leptin induced STAT3 phosphorylation
Paris et al., Eur J Pharmacol 2013 (Alzheimer Disease...) : Our data show that anatabine prevents STAT3 and NF?B phosphorylation induced by lipopolysaccharide (LPS) or TNF-a in SH-SY5Y, HEK293, human microglia and human blood mononuclear cells
Lan et al., PloS one 2012 : We found that TNF-a activated STAT3 at delayed time points ( 6 h and 24 h ), whereas conditioned medium collected from TNF-a treated NPCs induced an immediate STAT3 activation ... Further, we showed that TNF-a induced abundant amounts of the IL-6 family cytokines, including Leukemia inhibitory factor (LIF) and Interleukin 6 (IL-6), in human NPCs. TNF-a induced STAT3 phosphorylation and astrogliogenesis were abrogated by the addition of neutralizing antibody for LIF, but not for IL-6, revealing a critical role of autocrine secretion of LIF in TNF-a induced STAT3 activation and astrogliogenesis
Chakilam et al., Am J Pathol 2013 (Cell Transformation, Neoplastic...) : We identified a new function of DAPK in suppressing TNF induced STAT3 activation as DAPK siRNA knockdown and treatment with a DAPK inhibitor potentiated STAT3 activation, IL-6 mRNA expression, and secretion
Li et al., Zhonghua Nan Ke Xue 2013 : TNF-alpha + CAPE induced statistically lower expressions of IL-6 and p-STAT3 than TNF-alpha alone ( P < 0.05 )
Webber et al., Hepatology 1998 : The results demonstrate that TNF transiently activates NF-kappaB and STAT3 and increases the proliferative response of hepatocytes to HGF or TGF- by fourfold