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HIF1A — TLR2
Text-mined interactions from Literome
Regueira et al., Liver Int 2009
:
The aim of this study was to evaluate the
effects of cobalt chloride ( CoCl ( 2 ), a hypoxia mimicking agent ), tumour necrosis factor-alpha (TNF-alpha) and
toll-like receptor (TLR) -2 , -3 and -4 agonists on
HIF-1 alpha accumulation, and further on HIF-1 alpha mediated modulation of mitochondrial respiration in cultured human hepatocytes
Spirig et al., PloS one 2010
:
In this study, we show that exogenous as well as endogenous inflammatory stimuli for TLR4 and
TLR2 induce the expression of
HIF-1alpha in human monocyte derived DC under normoxic conditions ... In addition, we could show that
TLR stimulation
resulted in an increase of
HIF-1alpha controlled VEGF secretion