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AKT1 — THPO

Text-mined interactions from Literome

Kroner et al., J Biol Chem 2000 : alpha-Thrombin and thrombopoietin activate PKBalpha via PI-3K and trigger the concurrent phosphorylation of Thr ( 308 ) ( via PDK1 ) and Ser ( 473 ) ( via a not yet identified PDK2 )
Majka et al., Exp Hematol 2002 (MAP Kinase Signaling System) : Thrombopoietin , but not cytokines binding to gp130 protein coupled receptors, activates MAPKp42/44, AKT , and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets
Kanaji et al., Blood 2004 (Thrombocytopenia) : An observed increase in thrombopoietin mediated Akt phosphorylation in the truncated variant supported the hypothesis and led to the development of a model in which the GP Ibalpha cytoplasmic tail sequestered signaling proteins during megakaryocytopoiesis and, as such, became a critical regulator in the temporal sequence of events that led to normal megakaryocyte maturation
Kozuma et al., Journal of thrombosis and haemostasis : JTH 2007 : Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin mediated Akt activation , which prevents the cleavage of Bcl-xL
Yamazaki et al., Curr Opin Hematol 2009 : With the help of advances in confocal microscopy, laser scanning microscopy, and personal computer computational power over the last decade, it has become evident that thrombopoietin/c-Mpl signaling plays a role in HSC self-renewal and AKT-forkhead box O signaling in HSC dormancy