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CCR3 — TAT

Text-mined interactions from Literome

Marone et al., J Allergy Clin Immunol 2001 (HIV Infections) : Because Tat protein is actively released by HIV-1 infected cells, our results indicate a novel mechanism by which Fc epsilon RI ( + ) cells are rendered more susceptible to infection with CCR3-tropic HIV-1 isolates ; that is, two HIV-1 proteins, gp120 and Tat, trigger the release of cytokines critical for T ( H ) 2 polarization from Fc epsilon RI ( + ) cells, and Tat upregulates beta-chemokine receptor CCR3 on these cells
Marone et al., Immunol Rev 2001 (HIV Infections) : Extracellular Tat affects the directional migration of human FcepsilonRI+ cells, CCR3 expression and TH2 cytokines release ... In addition, Tat upregulates the beta-chemokine receptor CCR3 , making FcepsilonRI+ cells more susceptible to infection with CCR3 tropic HIV-1 isolates
Wang et al., Journal of thrombosis and haemostasis : JTH 2011 (Calcium Signaling...) : This activation by Tat requires the chemokine receptor CCR3 and ß3-integrin expression on platelets, as well as calcium flux