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CHUK — TAB2
Pathways - manually collected, often from reviews:
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KEGG NOD-like receptor signaling pathway:
Complex of MAP3K7-TAB1-TAB2-TAB3
→
Complex of CHUK-IKBKB-IKBKG
(protein-protein, activation)
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NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Devin et al., Immunity 2000, Yang et al., Nat Immunol 2001, Ducut Sigala et al., Science 2004, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
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Reactome Reaction:
CHUK
→
TAB2
(reaction)
Carter et al., J Biol Chem 2001, Wang et al., Nature 2001, Carter et al., J Biol Chem 2003, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Adhikari et al., Oncogene 2007, Israël et al., Cold Spring Harbor perspectives in biology 2010, Arch et al., Genes Dev 1998
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WikiPathways TLR4 Signaling and Tolerance:
Complex of MAP3K7-TAB2-TAB1
→
Complex of CHUK-IKBKB-IKBKG
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Suzuki et al., J Biol Chem 2007
(Cell Transformation, Viral...) :
Constitutive activation of TAK1 by HTLV-1 tax dependent overexpression of
TAB2 induces activation of JNK-ATF2 but not
IKK-NF-kappaB
Moussaieff et al., Mol Pharmacol 2007
:
IA inhibited
TAK/TAB mediated
IkappaB kinase (IKK) activation loop phosphorylation, resulting in the inhibition of cytokine and lipopolysaccharide mediated NF-kappaB activation
Prickett et al., J Biol Chem 2008
:
In kinase assays using TAK1 immune complexes, added
GST-TAB4 selectively
stimulated IKK phosphorylation