Gene interactions and pathways from curated databases and text-mining

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IL22 — STAT1

Pathways - manually collected, often from reviews:

  • BioCarta il22 soluble receptor signaling pathway: STATs (STAT3/STAT5A/STAT1/STAT5A/STAT5B/STAT5B) → IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) (modification, collaborate)
  • BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) → STATS/STATS complex (STAT3_STAT5A_STAT1_STAT5A_STAT5B_STAT5B) (modification, activates)

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1 , 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Lee et al., J Exp Med 1999 : Interestingly, interleukin (IL)-7 selectively activated STAT1 and induced MHC class I in mature T but not B cells
Nagalakshmi et al., Int Immunopharmacol 2004 : IL-22 induced the phosphorylation of STAT1 and STAT3 in Colo205, a colon epithelial cell line
Brand et al., Am J Physiol Gastrointest Liver Physiol 2006 (Crohn Disease...) : IL-22 binding to its receptor complex activates STAT1/3 , Akt, ERK1/2, and SAPK/JNK MAP kinases
Bachmann et al., Biochem Pharmacol 2013 : IFNa converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets ... Accordingly, only after IFNa pre-incubation was IL-22 induced STAT1 binding to the CXCL10 promoter detectable ... Using the viral mimic polyinosinic : polycytidylic acid and the IFNa/ß antagonist B18R we furthermore demonstrate the capability of endogenous IFN to promote IL-22 induced STAT1 activation and expression of CXCL10 ... IL-22 induced STAT1 activation subsequent to IFNa priming became likewise apparent in human Caco2 colon epithelial/carcinoma cells, HepG2 hepatoma cells, and primary keratinocytes