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HIF1A — SOD1
Text-mined interactions from Literome
Brunelle et al., Cell Metab 2005
(Anoxia) :
The expression of glutathione peroxidase or catalase, but not
superoxide dismutase 1 or 2,
prevents the hypoxic stabilization of
HIF-1 alpha
Takenaga et al., J Control Release 2006
(Movement Disorders...) :
HIF-1alpha gene expression increased following SCI, and
PC-SOD further
increased it ... In conclusion,
PC-SOD gradually accumulated and retained at the damaged site to scavenge excessive O2-, and suppressed neuronal death through reducing oxidative stress,
increasing neuroprotective factor production and
HIF-1alpha gene expression
Bonnet et al., Circulation 2006
(Anoxia...) :
Like FHRs, human PAH-PASMCs had dysmorphic, hyperpolarized mitochondria ; normoxic
HIF-1alpha activation ; and reduced expression/activity of HIF-3alpha, cytochrome c oxidase, and
superoxide dismutase-2
Jiang et al., J Exp Med 2007
(Cardiomyopathy, Hypertrophic...) :
HIF-1alpha coimmunoprecipitates with a Cu chaperone for superoxide dismutase-1 ( CCS ), and gene silencing of CCS, but not
superoxide dismutase-1 ,
prevents IGF-1- or Cu-induced
HIF-1alpha activation and VEGF expression