Gene interactions and pathways from curated databases and text-mining

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HIF1A — SOD1

Text-mined interactions from Literome

Brunelle et al., Cell Metab 2005 (Anoxia) : The expression of glutathione peroxidase or catalase, but not superoxide dismutase 1 or 2, prevents the hypoxic stabilization of HIF-1 alpha
Takenaga et al., J Control Release 2006 (Movement Disorders...) : HIF-1alpha gene expression increased following SCI, and PC-SOD further increased it ... In conclusion, PC-SOD gradually accumulated and retained at the damaged site to scavenge excessive O2-, and suppressed neuronal death through reducing oxidative stress, increasing neuroprotective factor production and HIF-1alpha gene expression
Bonnet et al., Circulation 2006 (Anoxia...) : Like FHRs, human PAH-PASMCs had dysmorphic, hyperpolarized mitochondria ; normoxic HIF-1alpha activation ; and reduced expression/activity of HIF-3alpha, cytochrome c oxidase, and superoxide dismutase-2
Jiang et al., J Exp Med 2007 (Cardiomyopathy, Hypertrophic...) : HIF-1alpha coimmunoprecipitates with a Cu chaperone for superoxide dismutase-1 ( CCS ), and gene silencing of CCS, but not superoxide dismutase-1 , prevents IGF-1- or Cu-induced HIF-1alpha activation and VEGF expression