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AKT1 — SMAD7

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AKT1 — SMAD7 (physical association, affinity chromatography technology) Song et al., EMBO J 2006*
• IRef Hprd Interaction: SMAD7 — AKT1 (in vivo) Song et al., EMBO J 2006*
• STRING interaction: AKT1 — SMAD7 (interaction, mapped from kegg_pathways)
• STRING interaction: AKT1 — SMAD7 (interaction, mapped from kegg_pathways)
• STRING interaction: SMAD7 — AKT1 (interaction, mapped from grid mint)
• STRING interaction: SMAD7 — AKT1 (interaction, mapped from grid mint)

Text-mined interactions from Literome

Lee et al., Int J Oncol 2004 (Stomach Neoplasms) : In contrast, PKB/Akt regulation by TGF-beta1 was not different in suspension or in adhesion, and Smad7 , but not the other Smads, activated PKB/Akt phosphorylation on TGF-beta1 treatment, indicating a specificity of Smad2 mediated and cell adhesion status dependent activation of Erk1/2 activity ... In contrast, PKB/Akt regulation by TGF-beta1 was not different in suspension or in adhesion, and Smad7 , but not the other Smads, activated PKB/Akt phosphorylation on TGF-beta1 treatment, indicating a specificity of Smad2 mediated and cell adhesion status dependent activation of Erk1/2 activity
Graham et al., Prostate 2009 (Neoplasm Metastasis...) : PI3K/Akt dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells
Sweetwyne et al., Am J Pathol 2010 : Collagen stimulation was independent of TGF-ß activity and Smad phosphorylation but was blocked by an Akt inhibitor, suggesting that signaling through the Akt pathway is important for regulation of collagen through TSP1 binding to calreticulin
Han et al., Int J Biochem Cell Biol 2013 : In addition, Smad activation inhibits muscle protein synthesis by suppressing Akt signaling