◀ Back to IGF1

IGF1 — SLPI

Text-mined interactions from Literome

Huang et al., J Bone Miner Res 2000 : IGF-I by itself did not stimulate 3H-proline incorporation, ALP , and osteocalcin in the models used, revealing that although IGF-I is essential for the anabolic effects of T3, it acts in concert with other factors to elicit these phenotypic responses
Miyakoshi et al., Endocrinology 2001 : Protease-resistant IGFBP-4 was more potent than wild-type IGFBP-4 in inhibiting IGF-I induced mouse osteoblast cell proliferation in vitro and in inhibiting IGF-I induced increase in alkaline phosphatase (ALP) activity in bone extract after local administration in vivo
Sakata et al., Bone 2003 : IGF-I significantly increased osteogenic colony number, total ALP activity, and total mineralization in bone marrow osteoprogenitor ( BMOp ) cells of normally loaded rats
Ohlsson et al., J Endocrinol 1992 : The effects of tri-iodothyronine ( T3 ) and insulin-like growth factor-I (IGF-I) on [ 3H ] thymidine incorporation, alkaline phosphatase (ALP) activity and IGF-I receptor mRNA levels were studied in rat epiphyseal chondrocytes cultured in monolayer ... Human GH ( hGH ; 50 micrograms/l ) and IGF-I ( 25 micrograms/l ) had no stimulatory effect on ALP activity
Katagiri et al., Biochem Biophys Res Commun 1990 : Dexamethasone, 1 alpha, 25-dihydroxyvitamin D3, transforming growth factor-beta 1 and insulin-like growth factor-I did not stimulate ALP activity
Li et al., Vet J 2009 : At concentrations of 10ng/mL and 100ng/mL, IGF-1 significantly induced ALP activity, OC level, matrix calcium content, and nodule formation of the osteoblastic cells by 20-180 % ( P < 0.05 or P < 0.01 ), compared to controls
Ochiai et al., J Biol Chem 2012 (Bone Diseases) : Surprisingly, exogenous and overexpressed IGF-1 recovered ALP activity and mRNA expression of osteoblast differentiation marker genes even with repeated TGF-ß1 administration ... Inhibition of IGF-1 signaling using small interfering RNA ( siRNA ) against insulin receptor substrate-1 (IRS-1) suppressed mRNA expression of RUNX2, ALP , BSP, and IGF-1 even with single TGF-ß1 administration
Kurose et al., Bone Miner 1989 : Thus, we conclude ( 1 ) that IGF-I stimulates both cell replication and differentiated functions in cultured murine osteoblasts and ( 2 ) that IGF-I and 1,25 ( OH ) 2D3 have the synergistic effect on ALP activity and the additive effect on collagen synthesis in MC3T3-E1 cells