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PTK6 — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT3 → PTK6 (increases, PTK6 Activity, STAT3 Activity)
  Evidence: In this study, we provide evidence that the signal transducer and activator of transcription 3, STAT3, is a physiological target of Brk. results in this study demonstrate that STAT3 is tyrosine phosphorylated and transcriptionally activated in cells expressing endogenous Brk. Signal transducer and activator of transcription 3 activation requires the catalytic activity of Brk

Text-mined interactions from Literome

van Puijenbroek et al., Exp Cell Res 1999 (Carcinoma, Embryonal) : Binding of Stat3 was inhibited by protein tyrosine kinase inhibitors, but not by the broad serine/threonine protein kinase inhibitor, H7
Shields et al., Cell cycle (Georgetown, Tex.) 2009 : We focus on the replication checkpoint and our recent findings that demonstrate that the attenuation of PTK mediated STAT3 signalling for the depletion of cyclin D1, works in concert with ATR instigated cascades for the suppression of S-phase progression
Gierut et al., Gastroenterology 2011 (Aberrant Crypt Foci...) : Induction of PTK6 increased apoptosis, proliferation, and STAT3 activation in Ptk6+/+ mice injected with azoxymethane ... Disruption of Ptk6 impaired STAT3 activation following azoxymethane injection, and reduced active STAT3 levels in Ptk6-/- tumors ... Disruption of Ptk6 reduced activity of STAT3 in young adult mouse colon cells ... PTK6 promotes STAT3 activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 activity in mouse colon tumors and in the HCT116 and young adult mouse colon cell lines
Gao et al., J Biol Chem 2012 (Neoplasms) : Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3
Nelson et al., J Biol Chem 1998 : Activation of STAT3 by the c-Fes protein-tyrosine kinase