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PRKAR2A — PTHLH

Text-mined interactions from Literome

Jemtland et al., J Bone Miner Res 1999 (Osteosarcoma) : Here we have characterized alternative PTHrP mRNA 3 ' splicing variants, encoding PTHrP isoforms of 139, 141, and 173 amino acids, and studied the regulation of PTHrP and its mRNAs by activated PKA and PKC in two human osteoblast-like cell lines ( KPDXM and TPXM ) ... Activation of PKA or PKC resulted in different effects on PTHrP and its mRNAs in the two cell lines
Deckelbaum et al., J Cell Sci 2002 : Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP mediated activation of PKA ... Conversely, overexpression of Ihh/N-Ihh or exogenous treatment with N-Shh led to dampening of PTHrP mediated activation of PKA
Yao et al., Med Sci Monit 2003 : The specific PKA inhibitor reduces MCP-1 gene expression and translation, as well as moderately reducing CSF-1 and PTHrP-R expression
Thomson et al., Exp Dermatol 2003 : We tested the effects of PTHrP on protein synthesis, protein kinase A (PKA) and protein kinase C ( PKC ) activities as well as tyrosine phosphorylation in rat vibrissa dermal papilla and capsular fibroblast cells
Hastings et al., Am J Physiol Cell Physiol 2004 (Lung Neoplasms...) : In summary, PTHrP- ( 1-34 ) and PTHrP- ( 140-173 ) stimulate PKA in lung carcinoma cells and protect cells against UV-induced caspase-3 activation and DNA fragmentation
Shimo et al., J Bone Miner Res 2006 (Bone Neoplasms...) : Furthermore, we found that CCN2 was induced by PTHrP through PKA- , PKC-, and ERK mediated pathways therein ... CCN2 was critically involved in osteolytic metastasis and was induced by PKA- and PKC dependent activation of ERK1/2 signaling by PTHrP