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IGF2 — PRL

Text-mined interactions from Literome

Fruchtman et al., Endocrinology 2000 : IGF-II and insulin also increased PRL release, but only at 10-fold higher concentrations than the lowest effective IGF-I dose
Kajimura et al., Gen Comp Endocrinol 2002 : By contrast, PRL ( 188 ) release was stimulated significantly and in a dose related manner by IGF-I at concentrations higher than 10 ng/ml and by IGF-II at concentrations higher than 100 ng/ml within 2h
Brisken et al., Dev Cell 2002 (Breast Neoplasms...) : Prolactin induces IGF-2 mRNA and IGF-2 induces cyclin D1 protein in primary MECs
Hovey et al., Mol Endocrinol 2003 : Insight into the mechanism by which PRL induced IGF-II expression was provided by the fact that it was blocked by the Jak2 inhibitor AG490 and the MAPK inhibitor PD98059
Peri et al., Cell Biol Int Rep 1992 : Neither Des-3-IGF-I nor IGF-II exhibited galactopoietic activity nor did they affect the galactopoietic activity of prolactin
Viengchareun et al., PloS one 2008 : That the effects of the lactogens in BAT are at least partly mediated by Insulin-like Growth Factor-2 (IGF-2) is supported by : i ) a striking reduction in BAT IGF-2 expression in PRLR KO mice and in PRLR-deficient preadipocytes ; ii ) induction of cellular IGF-2 expression by PRL through JAK2/STAT5 pathway activation ; and iii ) reversal of defective differentiation in PRLR KO cells by exogenous IGF-2
Carver et al., Mol Cancer Res 2008 (Breast Neoplasms...) : Here, we investigate the relationship between these factors and show that prolactin up-regulated transcript levels of both IGF-I and IGF-II , but only after increases in cyclin D1 protein were observed
Zvibel et al., Mol Cell Biol 1991 (Carcinoma, Hepatocellular...) : Heparin induction of all IGF II transcripts was also dependent on triiodotyronine and prolactin , but it is unknown whether their induction by heparin was via transcriptional or posttranscriptional mechanisms
Matsumoto et al., Mol Hum Reprod 2008 : MPA and E ( 2 ) induced decidualization of stromal cells, while LR ( 3 ) -IGF-I inhibited decidualization by MPA and E ( 2 ) as well as PRL and IGFBP-1 secretion into medium
Handwerger et al., Ann N Y Acad Sci 1991 : The demonstration that the synthesis and release of decidual prolactin are regulated by PRL-RF, IGF-I , insulin, relaxin, arachidonic acid, PRL-IF and lipocortin I strongly suggests that there is novel autocrine/paracrine feedback regulation between the placenta, fetal membranes, and decidua in the regulation of decidual prolactin
Shushanov et al., Bull Exp Biol Med 2011 : It was found that both IGF-1 and IGF-2 activate the expression of milk protein ß-casein in the presence of prolactin and hydrocortisone
Irwin et al., Regul Pept 1993 : The decrease in IGFBP-1 levels in decidualized stromal cultures was associated with the induction of mitogenesis by IGF-I and IGF-II, while IGF effects on prolactin secretion paralleled those of IGFBP-1 secretion, with stimulation ( 243-324 % ) in the low concentration range followed by inhibition at higher concentrations
Nakago et al., Nihon Naibunpi Gakkai Zasshi 1995 : To elucidate the effects of growth hormone (GH), prolactin (PRL) , and human placental lactogen (hPL) on the regulation of insulin-like growth factor ( IGF-1 ), we compared plasma IGF-1 levels, the pattern of circulating IGF-1-IGF binding protein complexes ( IGF-1 complexes ), and unsaturated binding protein ( USBP ) levels among 1 ) naturally growing Wistar rats at several developmental stages, 2 ) rats subcutaneously administered GH, and 3 ) hypophysectomized rats treated with each of the three hormones