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IGF2 — PPP1R3A

Text-mined interactions from Literome

Chen et al., Br J Pharmacol 2006 : The results indicate that Rg1 significantly increases IGF-IR expression and IGF-IR promoter activity in MCF-7 cells ( P < 0.05 ) ... Taken together, our results suggest that Rg1 not only increases IGF-IR expression but also enhances IGF-IR mediated signaling pathways in MCF-7 cells ... The stimulation of IGF-IR expression by Rg1 in MCF-7 cells appears to require ER, and its actions might involve ligand independent activation of ER
Lau et al., Br J Pharmacol 2009 (Breast Neoplasms...) : The effects of Rg1 on cell proliferation and IGF-IR protein expression were studied in the presence of tyrosine kinase inhibitor genistein to elucidate the involvement of tyrosine kinase in mediating these effects ... Rg1 induction of cell proliferation and IGF-IR protein expression was abolished by co-treatment with genistein