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IL12A — PGD

Text-mined interactions from Literome

Faveeuw et al., Eur J Immunol 2003 : In the present study, we show that PGD ( 2 ) inhibits , in a dose dependent manner, the CD40- and LPS induced secretion of the Th1 driving factor IL-12 by murine splenic dendritic cells ( DC ), the most potent antigen presenting cells ... Together these data suggest that PGD ( 2 ), by interacting with DP1 and by binding to other target cellular proteins, may regulate immune responses by affecting IL-12 production in DC
Gosset et al., J Immunol 2003 : Moreover, PGD ( 2 ) and 15d-PGJ ( 2 ) strongly reduce the secretion of the Th1 promoting cytokine IL-12 and affect the synthesis of chemokines involved in Th1 cell chemotaxis, particularly CXCL10