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PECAM1 — TLR4

Text-mined interactions from Literome

Khatri et al., Invest Ophthalmol Vis Sci 2002 (Keratitis) : These findings demonstrate that endotoxin induced keratitis is regulated by toll-like receptor-4 (TLR4) dependent expression of PECAM-1 and MIP-2, which are essential for recruitment of neutrophils to this site and for development of endotoxin induced stromal disease
Rui et al., J Immunol 2007 : PECAM-1 ligation negatively regulates TLR4 signaling in macrophages ... In addition, PECAM-1 ligation recruited Src homology region 2 domain containing phosphatase 1 ( SHP-1 ) and Src homology region 2 domain containing phosphatase 2 ( SHP-2 ) may be involved in the inhibitory effect of PECAM-1 on TLR4 signaling