Plachta et al., Exp Cell Res 2003
:
Paradoxically, long-term ( 12 h ) NOS inhibition caused an increase in PCD to compensate for the high proliferation rate under these conditions
Traister et al., Cell Death Differ 2004
:
These effects can be reversed by BMP-4 antagonists, such as follistatin and noggin, or by specific NOS inhibitors, resulting in low NO levels that facilitate mitosis and reduce PCD