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IGF2 — PAPPA

Pathways - manually collected, often from reviews:

• Reactome Reaction: PAPPA → IGF2 (reaction) Lawrence et al., Proc Natl Acad Sci U S A 1999*, Qin et al., Arch Biochem Biophys 2000*, Byun et al., J Clin Endocrinol Metab 2001*, Overgaard et al., J Biol Chem 2001, Laursen et al., FEBS Lett 2001, Schneider et al., Biochem Biophys Res Commun 2001, Baxter et al., J Clin Endocrinol Metab 2002, Laursen et al., Biochem J 2002*, Mohan et al., J Endocrinol 2002, Firth et al., Endocr Rev 2002, Zhou et al., J Endocrinol 2003*, Holly et al., Neuroendocrinology 2006, Gyrup et al., Biochemistry 2007*, Laursen et al., Mol Endocrinol 2007*

Text-mined interactions from Literome

Giudice et al., J Clin Endocrinol Metab 2002 : In decidualized stromal CM, PAPP-A/IGFBP-4 protease activity was also IGF-II dependent , but was evident only when IGF-II was added in molar excess of the predominant IGFBP in decidualized stromal cell CM, IGFBP-1, supporting bioavailable IGF-II as a key cofactor of IGFBP-4 proteolysis by PAPP-A ... In contrast to the experiments with trophoblasts, IGF-II and the IGF analogues, Leu ( 27 ) IGF-II, and Des ( 1-6 ) IGF-II, resulted in a dose dependent decrease of PAPP-A levels in decidualized endometrial stromal CM by 70-90 %, and a dose dependent increase in proMBP of 14- to 41-fold
Fortune et al., Anim Reprod Sci 2004 : Taken together, these results suggest a critical role for FSH induced PAPP-A , and thus for free IGF , in the selection of the DF
Bunn et al., Biochem Biophys Res Commun 2004 : These results demonstrate for the first time that PAPP-A is the IGFBP-4 protease in MC3T3-E1 cells, a widely used model for osteoblast development, and that PAPP-A may regulate IGF release throughout osteoblast differentiation
Aad et al., Domest Anim Endocrinol 2006 : The objective of this study was to determine the effect of IGF-I, IGF-II , insulin (INS), LH, FSH, estradiol ( E2 ), leptin or cortisol on ovarian PAPP-A mRNA levels
Cowans et al., Prenat Diagn 2007 (Body Weight...) : In those cases that eventually result in poor fetal growth, levels of PAPP-A and ADAM12 at 11-14 weeks are significantly lower than normal-in this instance, lowered PAPP-A and ADAM12 would result in less free IGF being available for cell uptake and growth stimulation
Gaidamauskas et al., Biochim Biophys Acta 2013 : Detailed knowledge of interactions between PAPP-A and its substrates is required to understand the modulatory role of PAPP-A on IGF receptor stimulation