Dreuw et al., J Invest Dermatol 2005
(Lichen Planus...) :
OSM additionally activated proteinkinase B strongly
Hosokawa et al., J Nutr Biochem 2010
(Periodontal Diseases) :
EGCG significantly prevented OSM induced phosphorylation of JNK, Akt ( Ser473 ) and STAT3 ( Tyr705 and Ser727 )
Henkel et al., Lab Invest 2011
(Fatty Liver...) :
OSM in turn attenuated insulin dependent Akt activation and, as a downstream target, glucokinase induction in hepatocytes, most likely by inducing suppressor of cytokine signaling 3 ( SOCS3 )