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NOD2 — TLR4

Text-mined interactions from Literome

Yang et al., J Immunol 2005 : Induction of Nod2 mRNA expression by LPS but not by TNF-alpha in osteoblasts was dependent on TLR4 and MyD88
Tohno et al., Mol Immunol 2008 : Furthermore, Toll-like receptor ( TLR ) and NOD2 ligands as well as immunobiotic lactic acid bacteria ( LAB ) enhanced the expression of NOD2 in gut associated lymphoid tissues (GALT) in adult and newborn swine
Ospelt et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid) : After up-regulation of NOD-2 by TLR ligands, its ligand muramyl dipeptide ( MDP ) increased the expression of IL-6 and IL-8 via p38 and NF-kappaB
Richardson et al., Gastroenterology 2010 (Disease Models, Animal...) : The effects of NOD2 on enterocyte TLR4 signaling and intestinal injury and repair were assessed in enterocytes lacking TLR4 or NOD2, in mice with intestinal-specific wild-type or dominant negative TLR4 or NOD2, and in mice with NEC ... NOD2 activation inhibited TLR4 in enterocytes, but not macrophages, and reversed the effects of TLR4 on intestinal mucosal injury and repair