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MMP2 — STAT3

Text-mined interactions from Literome

Xie et al., Oncogene 2004 (Melanoma...) : Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis ... Transfection of constitutively activated Stat3 into poorly metastatic C23 tumor cells directly activated the MMP-2 promoter, whereas the expression of a dominant negative Stat3 in highly metastatic C4 tumor cells inhibited the MMP-2 promoter ... Therefore, overexpression of MMP-2 in the metastatic melanoma cells can be attributed to elevated Stat3 activity, and Stat3 upregulates the transcription of MMP-2 through direct interaction with the MMP-2 promoter ... Collectively, these studies suggest that Stat3 signaling directly regulates MMP-2 expression, tumor invasion, and metastasis, and that Stat3 activation might be a crucial event in the development of metastasis
Xie et al., Cancer Res 2006 (Brain Neoplasms...) : Furthermore, altered Stat3 activity profoundly affected melanoma angiogenesis in vivo and melanoma cell invasion in vitro and significantly affected the expression of basic fibroblast growth factor (bFGF), vascular endothelial growth factor ( VEGF ), and matrix metalloproteinase-2 (MMP-2) in vivo and in vitro ... These results indicated that Stat3 activation plays an important role in dysregulated expression of bFGF, VEGF, and MMP-2 as well as angiogenesis and invasion of melanoma cells and contributes to brain metastasis of melanoma
Gao et al., Zhonghua Wai Ke Za Zhi 2008 (Pancreatic Neoplasms) : RNAi inhibition of STAT3 significantly suppressed the metastasis ability of SW1990 cells in vivo, and also markedly reduced the mRNA expression of MMP-2 and VEGF in SW1990 cells
Huang et al., Dig Dis Sci 2009 (Stomach Neoplasms) : Stat3 is involved in angiotensin II-induced expression of MMP2 in gastric cancer cells ... To examine the role of Stat3 in angiotensin II-induced MMP2 expression, A JAK-specific inhibitor and AG490 were used ... These results indicate that Stat3 may at least in part mediate angiotensin II-induced MMP2 mRNA expression in human gastric cancer cells
Chen et al., J Mol Neurosci 2010 (Brain Neoplasms...) : In addition, down-regulation of Stat3 can suppress the expression of MMP-2 , Bcl-xL and survivin but not 67LR
Wang et al., Oncol Res 2010 (Liver Neoplasms, Experimental...) : Inhibition of metastasis and angiogenesis was correlated with decreasing expression of STAT3, P-STAT3, MMP-2 , VEGF, and TGF-beta genes, regulated by STAT3 in MHCCLM6 cells
Kesanakurti et al., Oncogene 2013 (Cell Transformation, Neoplastic...) : In individual experiments, IL-6 or siRNA-insensitive MMP-2 overexpression by pM-FL-A141G counteracted and restored the pM-inhibited Stat3 DNA binding activity, suggesting IL-6/Stat3 signaling suppression in pM-treated 4910 and 5310 cells ... Our data indicate the possible role of MMP-2/a5ß1 interaction in the regulation of a5ß1 mediated IL-6/Stat3 signaling activation and signifies the therapeutic potential of blocking MMP-2/a5ß1 interaction in glioma treatment
Seo et al., J Biol Chem 2012 (Neoplasm Invasiveness...) : Similarly, inhibition of STAT3 suppressed the expression of MMP2 , thus leading to attenuated invasiveness of these ovarian cancer cells
Guo et al., Mol Cancer Ther 2013 (Neoplasm Invasiveness...) : NE-mediated activation of STAT3 was inhibited by blocking ß-adrenergic receptors ( AR ) and by blocking protein kinase A, but not through blocking a-AR. Blocking STAT3 could inhibit NE-induced NGF, MMP2 , and MMP9 expression and attenuate the migratory, invasive ability and PNI of pancreatic cancer cells