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HIF1A — MIF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MIF → HIF1A (increases)
  Evidence: In 2006, Baugh et al. [57] further revealed a possible role of MIF under hypoxic conditions. They describe HIF-1 as a potent inducer of MIF expression in hypoxia. Interestingly, these data were complemented by the works of Welford et al. [58] . They described the importance of HIF-1 in preventing cell senescence in a fibroblast model. Using HIF-1 knockout mice, they were able to show that under aerobic conditions lack of HIF-1 resulted in accelerated cellular aging and decreased cell prolifer...

Text-mined interactions from Literome

Baugh et al., Biochem Biophys Res Commun 2006 : Here we show that hypoxia, and specifically HIF-1alpha , is a potent and rapid inducer of MIF expression
Winner et al., Cancer Res 2007 (Adenocarcinoma...) : In studies designed to better understand hypoxia stimulated MIF function, we have discovered that not only is MIF induced by hypoxia in pancreatic adenocarcinoma but MIF is also necessary for maximal hypoxia induced HIF-1alpha expression
Winner et al., Methods Enzymol 2007 (Neoplasms) : The functional significance of hypoxia induced MIF expression is revealed by findings demonstrating that HIF-1alpha dependent MIF expression is necessary for hypoxia induced evasion from cell senescence and that MIF is necessary for HIF-1alpha stabilization induced by hypoxia and prolyl hydroxylase (PHD) inhibitors
Larsen et al., Cancer Lett 2008 (Breast Neoplasms) : Inhibition of HIF-1alpha , HIF-2alpha, NF-kappaB and C/EBPbeta using siRNA had no effect on hypoxia induced MIF secretion