Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase ( MAP3K ) that activates multiple mitogen activated protein kinase ( MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
López-Pelaéz et al., Mol Biol Cell 2012
(Inflammation...) :
Cot/tpl2 is the only MAP3K that activates MKK1/2-Erk1/2 in Toll-like receptor activated macrophages
Cuenda et al., Biochem J 1998
:
Here we demonstrate that MLK2 activates SAPK kinase-1 (SKK1)/MAPK kinase 4 ( MKK4 ) and SKK4/MKK7, the two known direct activators of SAPK1/JNK ( both in transfection studies and in vitro )