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CHUK — MAP3K1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CHUK → Complex of CHUK-MAP3K1 (directlyIncreases, CHUK/MAP3K1 Activity) Nemoto et al., Mol Cell Biol 1998*
  Evidence: MEKK1 interacts with and stimulates the activities of both IKKalpha and IKKbeta in transfected HeLa and COS-1 cells and directly phosphorylates the IKKs in vitro
• OpenBEL Selventa BEL large corpus: CHUK → MAP3K1 (increases, MAP3K1 Activity, CHUK Activity) Nemoto et al., Mol Cell Biol 1998*
  Evidence: Modified assertion
• OpenBEL Selventa BEL large corpus: CHUK → MAP3K1 (increases, MAP3K1 Activity, CHUK Activity) Lee et al., Proc Natl Acad Sci U S A 1998
  Evidence: We have previously shown that mitogen-activated protein kinase/ERK kinase kinase 1 (MEKK1) can induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IkappaB kinase complex in vitro.
• BioCarta nf-kb signaling pathway: LPS/TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• BioCarta nf-kb signaling pathway: TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• BioCarta nf-kb signaling pathway: TAB1/TAK1 complex (MAP3K7IP1-MAP3K7) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• KEGG MAPK signaling pathway: MAP3K1 → CHUK/IKBKB/IKBKG (protein-protein, phosphorylation)
• Reactome Reaction: CHUK → MAP3K1 (reaction) Li et al., J Biol Chem 2002, Solt et al., J Biol Chem 2009, Lee et al., Cell 1997, Lee et al., Proc Natl Acad Sci U S A 1998
• WikiPathways MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ: TRAF6/MAP3K14/MAP3K1 → Complex of IKBKB-CHUK-IKBKG (activation)
  
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): MAP3K1 → CHUK (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CHUK — MAP3K1 (direct interaction, enzymatic study) Lee et al., Proc Natl Acad Sci U S A 1998
• IRef Biogrid Interaction: CHUK — MAP3K1 (direct interaction, enzymatic study) Nemoto et al., Mol Cell Biol 1998*
• IRef Biogrid Interaction: CHUK — MAP3K1 (physical association, affinity chromatography technology) Nemoto et al., Mol Cell Biol 1998*
• IRef Biogrid Interaction: CHUK — MAP3K1 (direct interaction, enzymatic study) Li et al., J Biol Chem 2006*
• IRef Innatedb Interaction: CHUK — MAP3K1 (unknown, -) Hehner et al., Mol Cell Biol 2000*
• IRef Innatedb Interaction: Complex of MAP2K4-MAP3K1-CHUK (unknown, -) Lee et al., Int Immunopharmacol 2008*

Text-mined interactions from Literome

Zhao et al., J Biol Chem 1999 : The essential features of this cascade are that a mitogen activated protein kinase kinase kinase ( MAP3K ) activates an IkappaB kinase (IKK) that site-specifically phosphorylates IkappaB
Kempiak et al., J Immunol 1999 : Dominant-active MEKK1 also induced transfected IKK beta, but not IKK alpha , activity
Hu et al., Oncogene 1999 (MAP Kinase Signaling System) : Moreover, both IKK-alpha and -beta were activated by hematopoietic progenitor kinase-1 (HPK1) and MAPK/ERK kinase kinase-1 (MEKK1) specifically, suggesting that IkappaB/NF-kappaB is regulated through the HPK1-MEKK1 stress response signaling pathway
Nakano et al., Proc Natl Acad Sci U S A 1998 : Collectively, these results indicate that NIK and MEKK1 independently activate the IKK complex and that the kinase activities of IKKalpha and IKKbeta are differentially regulated by two upstream kinases, NIK and MEKK1, which are responsive to distinct stimuli ... Collectively, these results indicate that NIK and MEKK1 independently activate the IKK complex and that the kinase activities of IKKalpha and IKKbeta are differentially regulated by two upstream kinases, NIK and MEKK1, which are responsive to distinct stimuli
Lee et al., Proc Natl Acad Sci U S A 1998 : MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta ... We also show that MEKK1 can induce the activation of both IKK-alpha and IKK-beta in vivo ... We conclude that IKK-alpha and IKK-beta can mediate the NF-kappaB inducing activity of MEKK1
Nemoto et al., Mol Cell Biol 1998 : MEKK1 interacts with and stimulates the activities of both IKKalpha and IKKbeta in transfected HeLa and COS-1 cells and directly phosphorylates the IKKs in vitro