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CASP5 — MAP2K1

Text-mined interactions from Literome

Shiah et al., Mol Pharmacol 2001 : Involvement of Asp-Glu-Val-Asp directed, caspase mediated mitogen activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel induced apoptosis in HL-60 cells
Johnson et al., Urology 2002 (Prostatic Neoplasms) : Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage, increases bax/bcl-2 ratio, reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt, induces caspase dependent mitogen activated protein kinase kinase ( MEK ) cleavage and upregulation of MEK kinase-1, all potential markers of the apoptotic pathway
Nguyen et al., J Cell Physiol 2003 (Lung Neoplasms) : Inhibition of MEK1/2 but not PI-3 kinase blocked kaempferol induced cleavage of caspase-7 , PARP cleavage, and apoptosis
Nesterov et al., Cancer Res 2004 (Cell Transformation, Neoplastic...) : The expression of constitutively activated mitogen activated protein kinase kinase 1 enhanced caspase 8 recruitment and sensitized immortalized human embryonic kidney cells to TRAIL induced death
Zhou et al., Cell Prolif 2007 (MAP Kinase Signaling System) : The suppression of MEK1/ERK1/2 activation inhibited UV-induced expression of c-Fos and JunD and increased caspase 3 activity and cell death
Zhou et al., Toxicol Appl Pharmacol 2008 : Knockdown of JWA attenuated arsenic trioxide induced apoptosis, and was accompanied by significantly reduced activity of caspase-9 , enhanced Bad phosphorylation and inhibited MEK1/2 , ERK1/2 and JNK phosphorylations
Gao et al., J Appl Physiol 2008 : Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2 ... Addition of insulin to proteolytically active cells attenuated both responses within 4 h. Individually, inhibitors of either phosphatidylinositide 3-kinase (PI3K) or MEK1/2 partially blocked the insulin induced reduction in caspase-3 activity ; in combination, the inhibitors completely prevented insulin from attenuating caspase-3 activity