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LCK — MAPK14
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
p38alpha-beta-active (MAPK14/MAPK11)
(modification, activates)
Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
p38alpha-beta (MAPK14/MAPK11)
(modification, activates)
Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
Text-mined interactions from Literome
Rao et al., Proc Natl Acad Sci U S A 2002
:
Finally, analysis of a ZAP-70-deficient T cell line revealed that Cbl inhibited
Lck dependent
mitogen activated protein kinase activation, and an intact Cbl RING finger domain was required for this functional effect
Maulon et al., Blood 1998
:
Our results are consistent with a negative
role for
p56Lck on thrombin induced [ Ca2+ ] i release and p38
MAPK activation in Jurkat T-cell lines