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IRF3 — TLR4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IRF3 → TLR4 (increases, TLR4 Activity, IRF3 Activity) Cusson-Hermance et al., J Biol Chem 2005
  Evidence: In addition to activating NF-kappaB, TLR3/4 pathways also stimulate interferon regulatory factor 3 activation.
• Reactome Reaction: IRF3 → TLR4 (reaction) Fitzgerald et al., Nat Immunol 2003, Fitzgerald et al., J Exp Med 2003, Mori et al., J Biol Chem 2004, Hemmi et al., J Exp Med 2004, An et al., Immunity 2006, Panne et al., J Biol Chem 2007, Lin et al., Mol Cell Biol 1998
• Reactome Reaction: IRF3 → TLR4 (indirect_complex) Fitzgerald et al., J Exp Med 2003, Mori et al., J Biol Chem 2004, Hemmi et al., J Exp Med 2004, An et al., Immunity 2006, Lin et al., Mol Cell Biol 1998

Text-mined interactions from Literome

Sakaguchi et al., Biochem Biophys Res Commun 2003 : Although much has been studied about the activation of the transcription factor IRF-3 and induction of IFN-beta gene by the LPS mediated TLR4 signaling, definitive evidence is missing about the actual role of IRF-3 in LPS responses in vitro and in vivo
Takahasi et al., Nat Struct Biol 2003 : Transcription factor IRF-3 is post-translationally activated by Toll-like receptor ( TLR ) signaling and has critical roles in the regulation of innate immunity
Wietek et al., J Biol Chem 2003 : Interferon regulatory factor-3 mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa ... These results therefore indicate that IRF-3 mediated activation of the ISRE by TLR4 but not TLR3 requires the p65 subunit of NF-kappa B
Okamoto et al., Clin Diagn Lab Immunol 2004 (Neoplasms, Experimental) : Cytokine production, killer cell activities, maturation of dendritic cells, phosphorylation of mitogen activated protein kinases, and nuclear translocation of interferon-regulatory factor 3 induced by AILb-A were severely impaired in TLR4-deficient but not TLR2-deficient mice
Goriely et al., Blood 2006 : Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3 induced IL-12p35 gene activation
Cheng et al., J Immunol 2006 : IRF-3 is expressed ubiquitously and is activated by serine phosphorylation in response to viral infection or TLR signaling
Lundberg et al., Blood 2007 (Inflammation) : Furthermore, TLR3 stimulation did not activate NFkappaB, MAPKs, or IRF-3 in DCs and MOs, but was able to do so in ECs and RA-SF
Koziczak-Holbro et al., Eur J Immunol 2008 : TLR4 mediated IRF3 activation was intact in these cells
Abe et al., Arterioscler Thromb Vasc Biol 2008 (Inflammation...) : Statins inhibited TLR4 mediated activation of interferon ( IFN ) regulatory factor ( IRF)3 by either lipopolysaccharide (LPS) or palmitic acid, resulting in suppression of IFN-beta expression, but not that of NF-kappaB or JNK
McCoy et al., J Biol Chem 2008 : Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation ... IRF3 can be activated by Toll-like receptor 3 (TLR3) in response to the double stranded RNA mimic poly ( I-C ) and by TLR4 in response to lipopolysaccharide (LPS)
Xu et al., Mol Immunol 2008 : PTP1B inhibits TLR ligands induced activation of MAPKs, NF-kappaB, and IRF3 , furthermore, co-transfection of PTP1B inhibits both MyD88- and TRIF induced transcription of TNF-alpha and IFN-beta reporter genes in a dose dependent manner
Youn et al., Int Immunopharmacol 2009 : Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists
Knödler et al., Leukemia 2009 : IL-10 was found to downregulate MyD88, IRAK1 ( IL-1 receptor associated kinase ) and tumor necrosis factor receptor associated factor 6, essential adaptor molecules for TLR signaling, and to decrease TLR induced nuclear expression of the nuclear factor-kappaB transcription factors c-Rel and Rel-B as well as interferon regulatory factor (IRF)-3 and IRF-8
Seya et al., Immunol Rev 2009 (RNA Virus Infections) : In response to RNA stimulation, TLR3 recruits the Toll-interleukin 1 receptor domain ( TIR ) -containing adapter molecule 1 ( TICAM-1 ) adapter and induces IRF-3 activation followed by IFN-beta promoter activation
Wu et al., Hepatology 2009 : TLR stimulated expression of proinflammatory cytokines [ tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) ], and activation of IRF-3 was suppressed after up-regulation of HBV replication in HBV-Met cells
Lee et al., Biochem Pharmacol 2009 : Luteolin attenuated ligand independent activation of IRF3 or NFkappaB induced by TLR4 , TRIF, or TBK1, while it did not inhibit TLR oligomerization
Atzei et al., J Biol Chem 2010 : We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses TLR induced activation of NF-?B and interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses
Chiang et al., J Biol Chem 2012 (Calcium Signaling) : Previous work has demonstrated that TLR4 initiates NF-?B activation from the plasma membrane, but that subsequent TLR4 translocation to the endosomes is required for IRF3 activation ... In conclusion, our results describe a novel role of the PLC?2-IP ( 3 ) -Ca ( 2+ ) cascade in the LPS induced innate immune response pathway where release of intracellular Ca ( 2+ ) mediates TLR4 trafficking and subsequent activation of IRF3
Tong et al., Cell Res 2012 : NLRC5 ablation reduces MHC class I expression, and enhances IKK and IRF3 phosphorylation in response to TLR stimulation or viral infection
Dowling et al., J Nutr Biochem 2013 : Furthermore the c9,t11-CLA isomer inhibited both nuclear factor-?B ( NF-?B ) and IRF3 activation following TLR4 ligation while eicosapentaenoic acid ( EPA ) only suppressed NF-?B activation
Bagchi et al., Cytokine 2013 : TLR4 activation led to the translocation of the interferon regulatory factor 3 (IRF3) into the nucleus
Chattopadhyay et al., mBio 2013 (Bacterial Infections...) : The critical transcription factor for IFN induction, in both cases, is IRF-3 , which is activated by TLR3 or RIG-I signaling in response to virus infection and TLR4 signaling in response to bacterial infection
Zhong et al., Science signaling 2013 (MAP Kinase Signaling System...) : Deficiency in USP25 enhanced the extent of ubiquitination of TRAF3 and accelerated its degradation after TLR4 activation, which potentiated TLR4 induced activation of NF-?B ( nuclear factor ?B ) and MAPK ( mitogen activated protein kinase ) signaling, but inhibited activation of the transcription factor IRF3 ( interferon regulatory factor 3 )