Gene interactions and pathways from curated databases and text-mining

◀ Back to AKT1

AKT1 — ILK

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Troussard et al., Mol Cell Biol 1999 : ILK activates protein kinase B and inhibits the glycogen synthase kinase 3 ( GSK-3 ) activity in a phosphatidylinositol-3-kinase ( PI 3-kinase ) -dependent manner
Lynch et al., Oncogene 1999 : Mutation of this serine to aspartate or glutamate, but not alanine, in combination with the inactivating lysine mutation restores integrin linked kinase dependent phosphorylation of serine-473 of protein kinase B
Persad et al., Proc Natl Acad Sci U S A 2000 (Prostatic Neoplasms) : Transfection of dominant negative ILK and WT PTEN into these cells also results in the inhibition of PKB/Akt kinase activity ... Transfection of dominant negative ILK and WT PTEN into these cells also results in the inhibition of PKB/Akt kinase activity
D'Amico et al., J Biol Chem 2000 (Breast Neoplasms) : Inhibition of the PI 3-kinase and AKT/protein kinase B , but not of the p38, ERK, or JNK signaling pathways, reduced ILK induction of cyclin D1 expression ... Inhibition of the PI 3-kinase and AKT/protein kinase B, but not of the p38, ERK, or JNK signaling pathways, reduced ILK induction of cyclin D1 expression
Yoganathan et al., Biochem Pharmacol 2000 : A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser-473 but not the Thr-308 site in the PTEN mutant cells
Persad et al., J Biol Chem 2001 : Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin linked kinase : critical roles for kinase activity and amino acids arginine 211 and serine 343 ... Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin linked kinase : critical roles for kinase activity and amino acids arginine 211 and serine 343 ... A highly selective small molecule inhibitor of ILK activity also inhibits the ability of ILK to phosphorylate PKB/Akt in vitro and in intact cells ... A highly selective small molecule inhibitor of ILK activity also inhibits the ability of ILK to phosphorylate PKB/Akt in vitro and in intact cells
Tan et al., J Biol Chem 2002 : Overexpression of ILK stimulated NF-kappaB activity and inhibition of ILK or protein kinase B ( PKB/Akt ) suppressed this activation
Gary et al., J Neurochem 2003 : Instead, we show a requirement for ILK in integrin receptor induced Akt activation ... ILK was activated following integrin stimulation and dominant negative ILK blocked integrin mediated Akt activation and cell survival
Cruet-Hennequart et al., Oncogene 2003 (Adenocarcinoma...) : Inhibition of ILK by a pharmacological inhibitor results in inhibition of cell proliferation, PKB/Akt phosphorylation and increase of p27 ( Kip1 ) ... Inhibition of ILK by a pharmacological inhibitor results in inhibition of cell proliferation, PKB/Akt phosphorylation and increase of p27 ( Kip1 )
Troussard et al., J Biol Chem 2003 : Utilizing double stranded RNA interference ( siRNA ) as well as conditional knock-out of ILK using the Cre-Lox system, we now demonstrate that ILK is essential for the regulation of PKB/Akt activity ... Utilizing double stranded RNA interference ( siRNA ) as well as conditional knock-out of ILK using the Cre-Lox system, we now demonstrate that ILK is essential for the regulation of PKB/Akt activity
Persad et al., Cancer Metastasis Rev 2003 (Cell Transformation, Neoplastic...) : ILK can mediate the phosphorylation of a variety of intracellular substrates, most notable of which are : protein kinase B ( PKB/Akt ), glycogen synthase kinase-3 ( GSK-3 ) and myosin light chain
Fukuda et al., J Biol Chem 2003 : Third, PINCH-1 and ILK are required for optimal activating phosphorylation of PKB/Akt , an important signaling intermediate of the survival pathway ... Third, PINCH-1 and ILK are required for optimal activating phosphorylation of PKB/Akt , an important signaling intermediate of the survival pathway ... Whereas depletion of ILK reduced Ser473 phosphorylation but not Thr308 phosphorylation of PKB/Akt , depletion of PINCH-1 reduced both the Ser473 and Thr308 phosphorylation of PKB/Akt ... Whereas depletion of ILK reduced Ser473 phosphorylation but not Thr308 phosphorylation of PKB/Akt , depletion of PINCH-1 reduced both the Ser473 and Thr308 phosphorylation of PKB/Akt
Kaneko et al., J Cell Sci 2004 : VEGF induced phosphorylation of protein kinase B ( PKB/Akt ), a regulator of cell survival and apoptosis, on serine 473, but not on threonine 308, in an ILK dependent manner
Makino et al., Oncogene 2004 : Stable expression of ILK-KD in HER2/neu transformed cells suppressed Akt phosphorylation and the expression of IkappaB kinase alpha and beta ( IKKalpha and beta ) at both the protein and mRNA levels, preventing IkappaB-alpha degradation and NF-kappaB activation
Lee et al., Biochem Biophys Res Commun 2004 : TGFbeta mediated phosphorylation of Akt at Ser-473 was inhibited by dominant negative ILK and PI3K inhibitors, LY294002 and wortmannin
Yau et al., Cancer Res 2005 (Neovascularization, Pathologic...) : Inhibition of integrin linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR , Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine induced apoptosis in human orthotopic primary pancreatic cancer xenografts ... These results show in vivo evidence that ILK plays a prominent role in oncogenic phosphatidylinositol 3-kinase/PKB signaling in vivo with major impact on the mammalian target of rapamycin, signal transducers and activators of transcription 3, and forkhead in rhadomyosarcoma signaling pathways, suggesting that ILK inhibitors might show activity in pancreatic cancer patients
Edwards et al., Oncogene 2005 (Brain Neoplasms...) : Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth ... Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth ... We now demonstrate that ILK activity regulates PKB/Akt activity in glioblastoma cells ... We now demonstrate that ILK activity regulates PKB/Akt activity in glioblastoma cells
Nho et al., J Biol Chem 2005 : Role of integrin linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway ... Kinase dead ILK attenuated Akt phosphorylation and enhanced fibroblast apoptosis, whereas hyperactive and wild type ILK augmented Akt phosphorylation and protected fibroblasts from apoptosis ... These data establish that matrix derived mechanical forces sensed by beta1 integrin are capable of modulating ILK activity which regulates fibroblast viability via an Akt dependent mechanism
Zhang et al., Hepatology 2006 (Disease Progression...) : Our studies also showed that ILK is involved in the phosphorylation of ERK 1/2, p38 MAPK, JNK, and PKB and that selective inhibition of ILK expression by siRNA results in a significant decrease in their phosphorylation
Shi et al., Oncogene 2007 (Brain Neoplasms...) : Downregulation of either FAK or ILK expression inhibited SPARC mediated AKT phosphorylation, and targeting both FAK and ILK attenuated AKT activation more potently than targeting either FAK or ILK alone
Joshi et al., FASEB J 2007 : Integrin linked kinase (ILK) , a membrane proximal upstream regulator of Akt and GSK3beta, was considered a candidate signaling mediator for T-cad
Hehlgans et al., Radiother Oncol 2008 : ILK regulated AKT activity in a phosphatidylinositol-3 kinase (PI3K) dependent manner
Wang et al., J Cell Biol 2008 (Muscular Dystrophy, Animal) : ILK binds the cytoplasmic domain of beta1 integrin and mediates phosphorylation of protein kinase B (PKB)/Akt , which in turn plays a central role during skeletal muscle regeneration ... ILK binds the cytoplasmic domain of beta1 integrin and mediates phosphorylation of protein kinase B (PKB)/Akt , which in turn plays a central role during skeletal muscle regeneration
McDonald et al., Cancer Res 2008 (Breast Neoplasms...) : Rictor and integrin linked kinase interact and regulate Akt phosphorylation and cancer cell survival
Hinton et al., J Cell Mol Med 2008 (Breast Neoplasms...) : Upon stimulation by growth factors and chemokine ligands, integrin linked kinase mediates the phosphorylation of Akt Ser473, and glycogen synthase kinase-3
Fuchs et al., Cancer Res 2008 (Carcinoma, Hepatocellular...) : Mesenchymal cell lines were therefore experimentally transformed with kinase-inactive ILK ( KI-ILK ) with a resulting decrease in ILK activity and activation of AKT
Verreault et al., Oligonucleotides 2009 (Neoplasms) : siRNA mediated integrin linked kinase suppression : nonspecific effects of siRNA/cationic liposome complexes trigger changes in the expression of phosphorylated-AKT and mTOR independently of ILK silencing
Huang et al., Microcirculation 2010 (Mechanotransduction, Cellular) : ILK was localized to FA and silencing ILK promoted cell spreading, enhanced cell adhesion, reduced cell proliferation and reduced downstream phosphorylation of GSK-3beta and PKB/Akt ... ILK was localized to FA and silencing ILK promoted cell spreading, enhanced cell adhesion, reduced cell proliferation and reduced downstream phosphorylation of GSK-3beta and PKB/Akt
Wu et al., Am J Nephrol 2010 : LXA ( 4 ) inhibited the expression and activity of ILK and activation of Ras, ERK1/2, PI3-K and Akt in HK-2 cells stimulated by CTGF
Kalra et al., Oncogene 2010 : Time course studies suggest that ILK inhibition or silencing caused transient decreases in P-AKT ( ser473 ), which were not temporally related to Her2/neu downregulation
Taylor et al., Surgery 2011 (Neuroblastoma) : Integrin linked kinase (ILK) induces phosphorylation of Akt leading to an increase in cell survival
Hwangbo et al., J Biol Chem 2011 : Inhibition of mda-9/syntenin or expression of mutant ILK ( E359K ) significantly blocked the translocation of both ILK and Akt to the plasma membrane
Delcommenne et al., Proc Natl Acad Sci U S A 1998 : Phosphoinositide-3-OH kinase dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin linked kinase ... Phosphoinositide-3-OH kinase dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin linked kinase ... In addition, kinase-active ILK can phosphorylate PKB/AKT on serine-473, whereas kinase-deficient ILK severely inhibits endogenous phosphorylation of PKB/AKT on serine-473, demonstrating that ILK is involved in agonist stimulated, Pi(3)K dependent, PKB/AKT activation ... In addition, kinase-active ILK can phosphorylate PKB/AKT on serine-473, whereas kinase-deficient ILK severely inhibits endogenous phosphorylation of PKB/AKT on serine-473, demonstrating that ILK is involved in agonist stimulated, Pi(3)K dependent, PKB/AKT activation