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IL6R — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT3 → IL6R (increases, IL6R Activity, STAT3 Activity) Kim et al., Mol Cell Biol 1999
  Evidence: Signaling by the IL-6 receptor is mediated through the signal transducing subunit gp130 and involves the activation of Janus-associated kinases (JAKs), signal transducer and activator of transcription 3 (STAT3), and mitogen-activated protein (MAP) kinase.
• OpenBEL Selventa BEL large corpus: STAT3 → IL6R (increases, IL6R Activity, STAT3 Activity)
  Evidence: Modified assertion
• BioCarta role of erbb2 in signal transduction and oncology: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) → STAT3 (modification, activates)
• BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → STAT3 (modification, activates)
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer ) complex (STAT3) (modification, activates)
  Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3) (modification, activates)
  Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer ) complex (STAT3) (modification, activates)
  Kortylewski et al., J Biol Chem 2003
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1) (modification, activates)
  Kortylewski et al., J Biol Chem 2003
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (STAT3) (modification, activates) Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• Reactome Reaction: IL6R → STAT3 (reaction) Zhong et al., Science 1994, Gerhartz et al., J Biol Chem 1996, Hemmann et al., J Biol Chem 1996
• Reactome Reaction: IL6R → STAT3 (indirect_complex) Decker et al., Oncogene 2000*, Gerhartz et al., J Biol Chem 1996, Hemmann et al., J Biol Chem 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT3 — IL6R (physical association, affinity chromatography technology) Zhang et al., Mol Cell Biol 2000*
• IRef Hprd Interaction: IL6R — STAT3 (in vivo) Zhang et al., Mol Cell Biol 2000*
• IRef Ophid Interaction: STAT3 — IL6R (aggregation, confirmational text mining) Zhang et al., Mol Cell Biol 2000*
• IRef Ophid Interaction: STAT3 — IL6R (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Smola-Hess et al., J Gen Virol 2001 (Uterine Cervical Neoplasms) : Soluble interleukin-6 receptor activates the human papillomavirus type 18 long control region in SW756 cervical carcinoma cells in a STAT3 dependent manner
Qing et al., J Biol Chem 2004 : Work from Ian Kerr 's laboratory reveals that the gp130 linked interleukin-6 receptor , which usually activates STAT3 predominantly, activates STAT1 efficiently when STAT3 is absent
Lee et al., Mol Cancer Ther 2006 (Carcinoma, Squamous Cell...) : Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas
Oberg et al., Int Immunol 2006 : Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells
Zhang et al., PloS one 2013 : Furthermore, IL-6R overexpression enhanced IL-6 induced STAT3 activation in uninfected immortalized NPE cells in vitro, and promoted growth and tumorigenicity of EBV positive NPC cell line ( C666-1 ) in vivo