◀ Back to TLR4
IL18 — TLR4
Text-mined interactions from Literome
Iwadou et al., J Int Med Res 2002
(Gram-Negative Bacterial Infections...) :
The results suggest that gabexate mesilate induced inhibition of tumour necrosis factor-alpha (TNF-alpha) and
interleukin-18 (IL-18) production in LPS stimulated PBMCs is
due to the inhibition of the nuclear factor-kappa B activation pathway and/or inhibition of the processing pathway of pro-TNF-alpha and pro-IL-18, not to down-regulation of TLR-2 or
TLR-4
Netea et al., J Immunol 2004
(Chlamydophila Infections) :
Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88 dependent,
TLR2- and TLR4 independent
induction of
IL-18 release
Kramer et al., J Leukoc Biol 2006
(Crohn Disease) :
Moreover, they lack MDP induced enhancement of
TLR mediated tumor necrosis factor alpha,
interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Baruah et al., J Leukoc Biol 2006
:
C1q increases the phagocytosis of apoptotic cells by DC and the release of
interleukin-12 in the
presence of
TLR4 ligands and apoptotic cells ; PTX3 inhibits both events
Broad et al., Immunology 2007
:
In this study we have shown that, whilst NF-kappaB activation and production of TNF-alpha and
interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4, -5, -7 or -9, was
reduced by prior stimulation with
TLR4 , -5, -7 or -9 ligands, the primary stimulation of TLR3, which does not use the MyD88 pathway, did not reduce the TNF-alpha or interleukin-12 responses to subsequent TLR stimulation
Li et al., J Immunol 2007
:
Alum induced IL-1beta and
IL-18 production was not
due to enhancement of
TLR signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion
Shoma et al., Infect Immun 2008
:
When macrophages were stimulated with rPLY, the production of IL-1alpha, IL-1beta, and
IL-18 was strongly induced in a
TLR4 dependent manner, whereas lipopolysaccharide, a canonical TLR4 agonist, hardly induced these cytokines
Abdollahi-Roodsaz et al., Arthritis Rheum 2008
(Arthritis, Infectious...) :
Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with
TLR-4 mediated
interleukin-17 production
Hammad et al., Nat Med 2009
(Asthma...) :
TLR4 triggering on structural cells
caused production of the innate proallergic cytokines thymic stromal lymphopoietin, granulocyte-macrophage colony stimulating factor,
interleukin-25 and interleukin-33
Marsh et al., J Neurosci 2009
(Infarction, Middle Cerebral Artery...) :
TLR4 can
induce both IFNbeta and interferon stimulated genes through its adapter molecule
Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3 transcription factor
Lee et al., J Parasitol 2010
:
We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether
TLR and MUC expression is
regulated by interferon (IFN)-gamma,
interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Hutchinson et al., Neuroscience 2010
:
Live imaging of TLR4 activation in RAW264.7 cells and
TLR4 dependent
interleukin-1 release from BV-2 microglia revealed that amitriptyline blocked TLR4 signaling
Han et al., Vet Microbiol 2010
:
Involvement of
TLR21 in baculovirus induced
interleukin-12 gene expression in avian macrophage-like cell line HD11
Piconi et al., AIDS 2010
(HIV Infections) :
Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression,
interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010
(Hepatitis C, Chronic) :
Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of
interleukin 17 by naive CD4 ( + ) T cells in the
presence of
TLR ligands
Hanamsagar et al., Trends Immunol 2012
:
TLR signaling
triggers the transcriptional activation of
pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome ...
TLR signaling
triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and
pro-IL-18 that are processed into their active forms by the inflammasome
Xia et al., J Pineal Res 2012
(Inflammation) :
As expected, melatonin inhibited
TLR4 mediated tumor necrosis factor alpha ( TNF-a ),
interleukin (IL)-1ß , IL-6, IL-8, and IL-10 in LPS stimulated macrophages
Villacres et al., J Infect Dis 2012
(HIV Infections...) :
Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß),
interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a)
responses to Toll-like receptor (TLR) 3 and
TLR4 stimulation
Meldrum et al., J Biol Chem 2012
(Fibrosis...) :
Profibrotic effect of
interleukin-18 in HK-2 cells is dependent on stimulation of the Toll-like receptor 4 (TLR4) promoter and
increased TLR4 expression ...
IL-18 stimulates the
TLR4 promoter via AP-1 activation to increase TLR4 expression in TECs and stimulates profibrotic changes in TECs through increased TLR4 expression/signaling ... The results demonstrate that
IL-18 induces
TLR4 expression during unilateral ureteral obstruction and induces TLR4 expression in HK-2 cells via AP-1 activation
Li et al., eLife 2012
:
A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger
TLR13 dependent
interleukin-1ß production
Koblansky et al., Immunity 2013
(Genetic Predisposition to Disease...) :
Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is
required for
interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Rhee et al., J Surg Res 2013
(Ureteral Obstruction) :
IL-18 activation is
dependent on
Toll-like receptor 4 during renal obstruction ... We hypothesized that
IL-18 activation is
dependent on
Toll-like receptor 4 (TLR4) signaling during renal obstruction ...
IL-18 production and activation during renal obstruction is
dependent on intact
TLR4 signaling
Schamber-Reis et al., J Biol Chem 2013
(Disease Resistance...) :
Altogether, our results indicate the redundant and essential
role of nucleic acid sensing TLR3,
TLR7 and TLR9 in inducing
interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Brancato et al., Wound Repair Regen 2013
(Disease Progression...) :
The accumulation of CCL2, CX3CL1, tumor necrosis factor-a,
interleukin (IL)-6 , IL-10, IL-12, and interferon-? in wound fluids was not
TLR4 dependent