Melnikov et al., J Clin Invest 2001
(Acute Kidney Injury...) :
In wild-type animals, we found that ARF causes kidney IL-18 levels to more than double and induces the conversion of the IL-18 precursor to the mature form ... Finally, we confirmed histologically that caspase-1 ( -/- ) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration
Melnikov et al., J Clin Invest 2002
(Disease Models, Animal...) :
These results suggest a novel neutrophil independent mechanism of IL-18 mediated ischemic ARF Faubel et al., Transplantation 2005
(Acute Kidney Injury...) :
We therefore examined the effect CD4+ T cell depletion on the development of ischemic ARF and the activation of IL-18 Edelstein et al., Nephrol Dial Transplant 2007
:
We have recently demonstrated that the caspase-1 mediated production of IL-18 plays a deleterious role in ischaemic acute renal failure ( ARF ) which is independent of neutrophils and CD4+ T cells