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IGF1 — IL10
Text-mined interactions from Literome
Stearns et al., Clin Cancer Res 2003
(Prostatic Neoplasms) :
Northern blots, Western blots, and ELISAs showed that
IL-10 suppressed
IGF-I induction of MMP-2 and MT1-MMP mRNA synthesis in these cell strains ( P < 0.001 ) ... The data show that
IL-10 blocks
IGF-I activation of MMP-2 and MT1-MMP mRNA expression and protein synthesis in primary prostate cell strains
Kooijman et al., J Leukoc Biol 2004
:
Insulin-like growth factor-I stimulates
IL-10 production in human T cells ... We found that
IGF-I stimulated the secretion of the Th2 cytokine
interleukin (IL)-10 by 40-70 % in PHA stimulated PBMC ... IL-10 secretion was also stimulated in purified T cells, and we established that
IGF-I also
stimulated IL-10 mRNA expression by 100-150 % ... The monocyte activating bacterial cell-wall product lipopolysaccharide induced
IL-10 production in PBMC, but this was not
affected by
IGF-I
Méndez-Dávila et al., J Endocrinol Invest 2004
(Osteoporosis) :
We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and
interleukin-1 stimulated interleukin (IL)-6, transforming growth factor-beta1 ( TGF-beta1 ) and
insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Glazebrook et al., J Vasc Res 1998
:
Regulation of
insulin-like growth factor-1 expression in vascular endothelial cells by the inflammatory cytokine
interleukin-1