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HSP90AB1 — NOS1

Text-mined interactions from Literome

Song et al., Biochem J 2001 : But the direct effect of hsp90 on purified nNOS has not been determined yet ... hsp90 increased nNOS activity in a dose dependent manner with an EC ( 50 ) of 24.1+/-6.4 nM ... Further in vitro protein binding experiments confirmed that hsp90 increased the binding of CaM to nNOS
Billecke et al., J Biol Chem 2002 : hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase : geldanamycin mediated oxidant generation is unrelated to any action of hsp90
Bucci et al., Br J Pharmacol 2002 : 3. Geldanamycin ( 10 microM ), a specific inhibitor of heat shock protein 90 (hsp90) and N ( omega ) -nitro-L-arginine-methyl ester ( L-NAME, 100 microM ), a nitric oxide synthase inhibitor , significantly inhibited E2-induced vasorelaxation
Billecke et al., J Biol Chem 2004 : The role of hsp90 in heme dependent activation of apo-neuronal nitric-oxide synthase
Peng et al., J Biol Chem 2004 : The proteasomal degradation of nNOS is enhanced by suicide inactivation of nNOS or by the inhibition of hsp90 , which is a chaperone found in a native complex with nNOS