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HGF — TPO

Text-mined interactions from Literome

Yamashita et al., J Gastroenterol Hepatol 2000 (Liver Cirrhosis) : Among them, only hepatocyte growth factor/scatter factor ( HGF/SF ) enhanced TPO mRNA expression ; other growth factors ( epidermal growth factor and transforming growth factor-beta ) and cytokines ( erythropoietin, granulocyte-colony stimulating factor, granulocyte-macrophage-colony stimulating factor, interleukin (IL)-3, IL-6 and interferon-gamma ) did not ... Next, we examined TPO mRNA expression in the livers of rats with CCl4 induced cirrhosis, the effects of HGF/SF on hepatic TPO mRNA expression and peripheral platelet and bone marrow megakaryocyte counts in the cirrhotic rats ... These results suggest that HGF/SF is a possible regulatory factor for TPO gene expression and that HGF/SF increases platelet production through an enhancement of TPO mRNA expression in the livers of cirrhotic rats
Kosone et al., Lab Invest 2007 (Body Weight) : In an in vitro study, HGF induced TPO and GABP-alpha/beta expression and enhanced TPO promoter activity