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HEY1 — NOTCH4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Taylor et al., Microvasc Res 2002
(Neovascularization, Pathologic) :
Furthermore, both EC network formation and expression of activated notch 1 or
notch 4 induce expression of the bHLH transcription factor
HESR-1 and downregulate the known HESR-1 target VEGFR-2 ( KDR )
Takizawa et al., Nucleic Acids Res 2003
:
In this paper, we show that BMP2 enhances
Notch induced transcriptional activation of Hes-5 and
Hesr-1 in mouse neuroepithelial cells
Kokubo et al., Dev Biol 2005
:
Mouse
hesr1 and hesr2 genes are redundantly
required to mediate
Notch signaling in the developing cardiovascular system
Ross et al., Mol Endocrinol 2006
:
HRT1 , another basic-helix-loop-helix protein and potential Hes-1 partner, was also
induced by
Notch in 3T3-L1 cells but did not block adipogenesis, suggesting that Hes-1 functions primarily as a homodimer or possibly as a heterodimer with an unknown partner
Ader et al., Mech Dev 2006
:
In addition, TGFbeta/BMP signaling pathway members including the type I TGFbeta receptor and Smads 3, 4 and 5 were significantly up regulated, as were several TGFbeta/BMP responsive genes including
Hey 1 , a
regulator of
Notch pathway signaling
Havrda et al., Thromb Haemost 2006
:
Activation of Notch1 and
Notch4 induced the VSMC-selective target genes
HRT1 and HRT2, promoted cell cycle transit in smooth muscle cells, and led to loss of density dependent growth inhibition
Li et al., Microvasc Res 2006
(Retinal Neovascularization) :
HESR1 is a downstream target of Notch in endothelial cells and could be an
effector of
Notch signaling in these cells
Hu et al., Immunity 2008
:
TLR- and
Notch induced Hes1 and
Hey1 attenuated IL-6 and IL-12 production
Keuylian et al., J Biol Chem 2012
(Carotid Artery Injuries...) :
Conversely,
Notch activation resulted in blocking AC8 expression and
up-regulated Hrt1 and Hrt3 expression