Calderone et al., J Neurosci 2004
(Brain Ischemia) :
Early CaEDTA also blocked mitochondrial release of cytochrome c and Smac/DIABLO ( second mitochondria derived activator of caspases/direct inhibitor of apoptosis protein binding protein with low pI ), caspase-3 activity ( but not procaspase-3 cleavage ), p75NTR induction , and DNA fragmentation
Mediavilla-Varela et al., Molecular cancer 2009
(Prostatic Neoplasms) :
Docetaxel induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75