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AKT1 — GRP

Text-mined interactions from Literome

Lee et al., J Neurochem 2002 : Up-regulation of GRP proteins and activation of JNK, PKCgamma and Akt may be critical for neuroprotection and the survival of bats during the repeated process
Qiao et al., Cancer Lett 2006 (Neuroblastoma) : Gastrin releasing peptide (GRP) activates phosphatidylinositol 3-kinase (PI3-K)/Akt , an important cell survival signaling pathway, to stimulate growth of various cell types
Liu et al., Exp Cell Res 2007 (Carcinoma, Non-Small-Cell Lung...) : Gastrin releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib ... GRP induced Akt activation primarily through c-Src mediated transactivation of EGFR ... Transfection of dominant negative c-Src abolished GRP induced EGFR and Akt activation ... GRP induced release of amphiregulin, and pre-incubation with human amphiregulin neutralizing antibody eliminated GRP induced Akt phosphorylation ... These results suggest that GRP stimulates Akt activation primarily via c-Src activation, followed by extracellular release of the EGFR ligand amphiregulin, leading to the activation of EGFR and PI3K
Ishola et al., Biochim Biophys Acta 2007 (Neuroblastoma) : GRP or BBS treatment rapidly increased phosphorylation of Akt and GSK-3beta in neuroblastoma cells
Dai et al., J Biol Chem 2012 (Carcinoma, Hepatocellular...) : Both p38 MAPK promoted glucose regulated protein 78 (GRP78) expression and sustained high basal activation of PI3K/Akt and MEK/ERK are involved in the cytoprotective function of p190Met ( NC )