Gene interactions and pathways from curated databases and text-mining

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AKT1 — GRM1

Text-mined interactions from Literome

Shin et al., Pigment Cell Melanoma Res 2010 (Cell Transformation, Neoplastic...) : In cultured stable Grm1-mouse-melanocytic clones, as well as an metabotropic glutamate receptor 1 ( Grm1 ) expressing human melanoma cell line, C8161, stimulation of Grm1 by its agonist led to the activation of AKT, while preincubation with Grm1-antagonist abolished Grm1-agonist induced AKT activation
Ribeiro et al., J Neurosci 2010 (Disease Models, Animal...) : Furthermore, mGluR1/5 stimulated AKT and extracellular signal regulated kinase ( ERK ) activation is altered in Hdh ( Q111/Q111 ) mice
Wangari-Talbot et al., Mol Cancer Res 2012 (MAP Kinase Signaling System...) : We showed that suppression of GRM1 expression in several human melanoma cell lines resulted in a reduction in the number of viable cells and a decrease in stimulated mitogen activated protein kinase ( MAPK ) and PI3K/AKT and suppressed tumor progression in vivo