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GATA3 — IL5
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ferber et al., Clin Immunol 1999
:
We now show that ectopic expression of
GATA-3 in developing Th1 cells significantly
inhibits IFN-gamma, as well as enhancing IL-4 and
IL-5 production
Christodoulopoulos et al., J Allergy Clin Immunol 2001
(Asthma...) :
The transcription factors
GATA-3 and cMAF
mediate IL-4 and
IL-5 synthesis, whereas signal transducer and activator of transcription 6 ( STAT-6 ) is critical for IL-4R signaling
Zhou et al., J Exp Med 2001
:
We show that FOG-1 can repress
GATA-3 dependent activation of the
IL-5 promoter in T cells
Takemoto et al., J Immunol 2002
:
The selective use of the N-finger may underlie the differential
roles of
GATA-3 in the induction of IL-4, IL-13, and
IL-5
Wang et al., J Immunol 2006
:
GATA-3 strongly
activated IL-4,
IL-5 , and IL-13 expression in conventional T cells but had comparatively weak effects on these cytokines in NKT cells
Barnes et al., Curr Mol Med 2008
(Asthma...) :
In addition
GATA-3 is
essential for the gene expression of the cytokines IL-4,
IL-5 and IL-13 that mediate allergic inflammation
Lee et al., Life Sci 2011
:
This study suggests that downregulation of
GATA-3 and c-Maf via the suppression of p38, IKK-ß and I?B-a phosphorylation might
contribute to the inhibitory effect of shikonin on mitogen induced IL-4 and
IL-5 production in EL-4T cells
Siegel et al., J Biol Chem 1995
(Lymphoma) :
Taken together, our data suggest that activation via the unique sequence combination
GATA/CLE0 results in selective expression of the
IL-5 gene in response to elevated levels of intracellular cAMP
Zhang et al., J Biol Chem 1997
:
Transcription factor
GATA-3 is differentially expressed in murine Th1 and Th2 cells and
controls Th2-specific expression of the
interleukin-5 gene ... We previously established a critical
role for the transcription factor
GATA-3 in
IL-5 promoter activation in EL-4 cells, which express both Th1- and Th2-type cytokines ... Our studies reported here demonstrate that
GATA-3 is
critical for expression of the
IL-5 gene in bona fide Th2 cells ... Whereas mutations in the GATA-3 site abolished antigen- or cAMP stimulated IL-5 promoter activation in Th2 cells, ectopic expression of
GATA-3 in Th1 cells or in a non-lymphoid, non-IL-5 producing cell line
activated the
IL-5 promoter
Zhang et al., J Immunol 1998
:
Here, we show that ectopic expression of
GATA-3 is
sufficient to drive
IL-5 but not IL-4 gene expression ... The
induction of
IL-5 gene expression by
GATA-3 involves high affinity binding of GATA-3 to an inverted GATA repeat in the IL-5 promoter