Gene interactions and pathways from curated databases and text-mining

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FOXP3 — TLR4

Text-mined interactions from Literome

Bell et al., J Immunol 2007 : We hypothesized that the transcription factor forkhead box P3 (FOXP3) regulates the expression of TLR family members in human Treg cells
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
de Kivit et al., Immunobiology 2011 (Inflammation) : TLR4 ligation of IEC ( HT-29 ) enhanced the production of TNF-a and IEC derived MDC and decreased numbers of Foxp3 ( + ) regulatory T cells
Jia et al., Mol Med Report 2012 : Foxp3 expression in A549 cells is regulated by Toll-like receptor 4 through nuclear factor-?B ... We hypothesised that TLR4 may also be involved in the regulation of Foxp3 in A549 cells through NF-?B ... Therefore, we examined the effect of TLR4 and NF-?B on the expression of Foxp3 in the A549 lung cancer cell line ... These results suggest that TLR4 is involved in the regulation of Foxp3 in A549 cells through NF-?B