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FOSL1 — MAPK3

Text-mined interactions from Literome

Balmanno et al., Oncogene 1999 : The expression of c-Fos, Fra-1 and JunB was dependent upon the activation of MAPK since these responses were inhibited by PD098059 ... However, a comparison of responses to FBS, thrombin, TRPs, LPA and EGF revealed that Fra-1 and JunB expression required sustained activation of MAPK whereas c-Fos expression was strongly induced even by non-mitogenic stimuli which elicited only transient MAPK activation
Hurd et al., Biochem J 2002 : Dual role for mitogen activated protein kinase ( Erk ) in insulin dependent regulation of Fra-1 ( fos related antigen-1 ) transcription and phosphorylation
Camalier et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Cell Transformation, Neoplastic...) : Supplementation of medium with phosphate increased anchorage independent transformation and proliferation of BALB/c mouse JB6 epidermal cells, activation of N-ras, ERK1/2 , and activator protein-1, and increased gene expression of Fra-1 , COX-2, and osteopontin in a dose dependent manner
Cook et al., Mol Cell Biol 1999 : In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ), we observed that selective, sustained activation of Raf-MEK-MAPK was sufficient to induce expression of Fra-1 , Fra-2, and JunB but, interestingly, induced little or no c-Fos or c-Jun ... These results suggest that kinetically distinct phases of MAPK activation serve to regulate the expression of distinct AP-1 components such that sustained MAPK activation is required for the induced expression of Fra-1 , Fra-2, c-Jun, and JunB