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AKT1 — ERBB2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Stoica et al., Oncogene 2003
:
Akt phosphorylation was
blocked by inhibitors of phosphatidylinositol 3-kinase (PI 3-K), by antiestrogens, the protein tyrosine kinase inhibitor, genistein, and by AG825, a selective
ErbB2 inhibitor ; but not by AG30, a selective EGFR inhibitor
Stoica et al., Oncogene 2003
(Breast Neoplasms) :
In contrast, in cells stably transfected with either a dominant negative Akt or with
R25C-Akt , as well as in parental cells in the
presence of a selective
ErbB2 inhibitor, the effect of estradiol on anchorage dependent and -independent cell growth was inhibited by 50-75 and 100 %, respectively
Xu et al., Cancer Res 2003
(Breast Neoplasms) :
AKT , a serine/threonine kinase that promotes cell survival, can be
activated by overexpression of the receptor tyrosine kinase
ErbB2 ... Conversely, down-regulation of
ErbB2 inhibits
AKT activation ... Inhibition of
ErbB2 by either the HSP ( heat shock protein ) 90 inhibitor geldanamycin or the ErbB inhibitor ZD1839 in SKBR3 cells, a human breast cancer cell line overexpressing ErbB2 protein,
induces a rapid and dramatic decrease in
AKT activity
Xia et al., Oncogene 2004
(Breast Neoplasms) :
Inhibition of
p95ErbB2 , p185ErbB2, and EGFR phosphorylation by GW572016
resulted in the inhibition of downstream phospho-Erk1/2,
phospho-AKT , and cyclin D steady-state protein levels
Tan et al., Cancer Res 2005
(Breast Neoplasms...) :
Our studies revealed two novel mechanisms that are involved in Src protein up-regulation and activation by ErbB2 : ( a )
ErbB2 increased Src translation through activation of the
Akt/mammalian target of rapamycin/4E-BP1 pathway and ( b ) ErbB2
increased Src stability most likely through the inhibition of the calpain protease
Machida et al., Cancer Sci 2005
(Carcinoma, Squamous Cell) :
However, in all three cell lines, 17AAG increased radiation induced apoptosis by reducing the expression of EGFR and
ErbB-2 and
inhibiting the phosphorylation of
Akt
Scheving et al., Am J Physiol Gastrointest Liver Physiol 2008
:
Cultured rat hepatocytes upregulate
Akt and ERK in an
ErbB-2 dependent manner
Coticchia et al., Breast Cancer Res Treat 2009
(Breast Neoplasms) :
However, forced overexpression of either epidermal growth factor receptor (EGFR) or
ErbB2 did partially
restore calmodulin dependent EGF stimulated
Akt activation
Kim et al., Cancer Lett 2009
(MAP Kinase Signaling System...) :
Overexpression of
ErbB2 significantly
activated p38 MAPK and
Akt , while Raf-1/MEK/ERK pathway was not activated by ErbB2
Madson et al., Am J Pathol 2009
(Cell Transformation, Neoplastic...) :
Since Akt phosphorylates Chk1-Ser ( 280 ), the
effect of
Erbb2 on phosphatidyl inositol-3-kinase
(PI3K)/Akt signaling during UV-induced cell cycle arrest was determined
Wang et al., J Biol Chem 2010
(Wounds and Injuries) :
Engagement of LN332 or clustering of the alpha6beta4 integrin with integrin-specific antibodies causes phosphorylation of
ErbB2 , Fyn, and the beta4 subunit as well as
activation of phosphatidylinositol 3-kinase and
Akt and their assimilation into this complex
Porzia et al., J Immunol 2010
(Mammary Neoplasms, Experimental) :
In conclusion, vaccine induced anti-ErbB2 Abs directly affected the transformed phenotype of rat ErbB2 ( + ) tumors by impairing
ErbB2 mediated
PI3K/Akt signaling
Lokeshwar et al., Cancer Res 2010
(Neoplasm Invasiveness...) :
4-MU
induced caspase-8, caspase-9, and caspase-3 activation, PARP cleavage, upregulation of Fas-L, Fas, FADD and DR4, and downregulation of bcl-2, phosphorylated bad, bcl-XL, phosphorylated
Akt , phosphorylated IKB, phosphorylated
ErbB2 , and phosphorylated epidermal growth factor receptor
Manandhar et al., Free Radic Biol Med 2012
(Ovarian Neoplasms) :
Repression of
ErbB2 led to a decrease in
phospho-AKT and enhanced p27 protein, reinforcing the effect of NRF2 knockdown on SKOV3 growth