Gene interactions and pathways from curated databases and text-mining

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CXCR4 — EGFR

Text-mined interactions from Literome

Porcile et al., Ann N Y Acad Sci 2004 (Adenocarcinoma...) : CXCR4 activation induces epidermal growth factor receptor transactivation in an ovarian cancer cell line
Rahimi et al., Int J Cancer 2010 (Breast Neoplasms...) : EGFR variant mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms
Abhold et al., PloS one 2012 (Carcinoma, Squamous Cell...) : Activation of EGFR by the addition of EGF ligand or ectopic expression of EGFR in two established HNSCC cell lines ( UMSCC-22B and HN-1 ) resulted in the induction of CD44, BMI-1, Oct-4, NANOG, CXCR4 , and SDF-1
Zhao et al., PloS one 2012 (MAP Kinase Signaling System) : The inhibition of CXCL12 or CXCR4 by either neutralizing antibodies or small interfering RNA ( siRNA ) could completely block the CsA induced EGFR phosphorylation
Weekes et al., Neoplasia (New York, N.Y.) 2012 (Pancreatic Neoplasms) : Next, CXCR4 promoted intratumoral EGFR expression in association with temsirolimus resistance ... Next, CXCR4 promoted intratumoral EGFR expression in association with temsirolimus resistance