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AKT1 — ECM2

Text-mined interactions from Literome

Kim et al., FEBS Lett 2005 : In the presence of FGF2, which is normally required for proliferation in an undifferentiated state, inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt/PKB signal stimulated differentiation and attenuated the expression of extracellular matrix ( ECM ) molecules
Martínez-Salgado et al., Exp Cell Res 2006 : Akt activation is higher in double KO fibroblasts than in heterozygotes ; inhibition of Akt activation also inhibits ECM synthesis ... PI3K-Akt pathway activation may be involved in the increase in ECM synthesis observed in the absence of H- and N-Ras
Xin et al., Am J Physiol Endocrinol Metab 2007 (Diabetes Complications...) : In this study, we investigated the role of Akt1 in ECM protein production in the organs affected by chronic diabetic complications
Kang et al., Int J Mol Med 2008 (Cell Transformation, Neoplastic) : ECM from fibroblasts in UVB-SIPS activates FAK, ERK, and AKT in HaCaT cells ... ERK and PI3K/AKT inhibitors inhibit ECM induced ERK, AKT activation and cell proliferation
Dai et al., PloS one 2012 (Acute Disease...) : Here, we demonstrate for the first time that acute ECM results in significantly reduced activation of protein kinase B ( PKB or Akt ) leading to decreased Akt phosphorylation and inhibition of the glycogen kinase synthase ( GSK3ß ) in the brains of mice infected with Plasmodium berghei ANKA ( PbA ) compared to uninfected controls and to mice infected with the non-neurotrophic P. berghei NK65 ( PbN ) ... Here, we demonstrate for the first time that acute ECM results in significantly reduced activation of protein kinase B ( PKB or Akt ) leading to decreased Akt phosphorylation and inhibition of the glycogen kinase synthase ( GSK3ß ) in the brains of mice infected with Plasmodium berghei ANKA ( PbA ) compared to uninfected controls and to mice infected with the non-neurotrophic P. berghei NK65 ( PbN )