Schattenberg et al., Hepatology 2004
(MAP Kinase Signaling System) :
The effect of CYP2E1 overexpression on MAPK activation and their function in altering death responses of CYP2E1 overexpressing hepatocytes were investigated ... Chronic CYP2E1 overexpression led to increased extracellular signal regulated kinase 1/2 ( ERK1/2 ) activation constitutively and in response to oxidant stress from the superoxide generator menadione
Wang et al., Free Radic Biol Med 2009
(Drug-Induced Liver Injury...) :
These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum TNF-alpha levels, and activation of MAPK