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CXCR4 — HIF1A
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Phillips et al., J Biol Chem 2005
(Anoxia...) :
A molecular analysis of these events indicated that augmented CXCR4 expression was regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signal transduction pathway,
activation of
hypoxia inducible factor (HIF) 1alpha , and ultimately HIF-1 dependent transcription of the
CXCR4 gene
Maréchal et al., Br J Cancer 2009
(Adenocarcinoma...) :
CXCR4 and CXCR7 expressions were positively correlated to HIF-1alpha suggesting a potential
role of
HIF-1alpha in
CXCR4 and CXCR7 transcription activation
Melchionna et al., Cardiovasc Res 2010
(Acidosis...) :
Role of
HIF-1alpha in proton mediated
CXCR4 down-regulation in endothelial cells ... The inhibition of
CXCR4 expression occurred transcriptionally and was hypoxia-inducible factor
(HIF)-1alpha dependent as demonstrated by both HIF-1alpha and HIF-1alpha dominant negative overexpression, by HIF-1alpha silencing, and by targeted mutation of the -29 to -25 hypoxia response element ( HRE ) in the -357/-59 CXCR4 promoter fragment