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CXCL10 — CXCR4
Pathways - manually collected, often from reviews:
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KEGG Chemokine signaling pathway:
CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2
→
CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1
(protein-protein, activation)
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Reactome Reaction:
CXCL10
→
CXCR4
(reaction)
Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994
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WikiPathways Chemokine signaling pathway:
CCL19/CCL27/CXCL3/CXCL10/XCL1/CXCL9/CCL21/CCL1/CCL11/CCL7/CCL17/CCL20/CCL22/CCL25/CCL27/CCL3/CCL4/CCL5/CCL15/CCL7/CCL15/CXCL3/CXCL5/CX3CL1/CXCL12/CCL19/CCL26/CXCL13/CXCL11/CCL24/PF4/CCL28/CXCL14/PPBP/CCL21/CXCL16
→
CXCR5/CCR6/CXCR2/CXCR3/CXCR4/CCR1/CCR9/CCR1/CCR3/CCR2/CCR4/CCR2/CCR7/CCR8/CCR10/CX3CR1/CXCR2/XCR1/CXCR6
(activation)
Text-mined interactions from Literome
Wan et al., Blood 2004
:
The induction of
interferon-gamma-inducible protein 10 ( IP-10 ) secretion by Hsp70L1 is not shared by Hsp70, and other functional differences include more potent stimulation of DC IL-12p70, CC-chemokine, and CCR7 and
CXCR4 expression by Hsp70L1. Immunization of mice with the hybrid peptide Hsp70L1-ovalbumin ( OVA ) ( 257-264 )
induces an OVA ( 257-264 ) -specific Th1 response and cytotoxic T lymphocyte ( CTL ) that results in significant inhibition of E.G7-OVA tumor growth
Lande et al., J Immunol 2004
(Arthritis...) :
We also show that CXCR3 and
CXCR4 are expressed by both blood derived pDCs and pDCs isolated from RA and PA SF and that
CXCL-10 , CXCL-11, and CXCL-12 present in RA and PA SF
stimulate chemotaxis of blood derived pDCs
Nagpal et al., J Endocrinol 2004
(Leydig Cell Tumor...) :
The purpose of the present study was to determine the
effects of overexpression of
CXCL10 by transfection experiments in MA-10 cells on cell growth,
CXCR3 expression, progesterone synthesis and steroidogenic acute regulatory protein ( StAR D1, a key regulatory factor in steroidogenesis ) gene expression
Song et al., PloS one 2009
(Breast Neoplasms...) :
When added from the basal side,
CXCL12 acts through receptor
CXCR4 on endothelium to promote adhesion of circulating breast cancer cells, independent of CXCL12 receptors CXCR4 or CXCR7 on tumor cells
Man et al., Sci Transl Med 2012
(Inflammation) :
Unexpectedly,
CXCL12 selectively
down-regulated CXCR4 on transmigrating monocytes, but not T cells