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CTNNB1 — STAT3

Text-mined interactions from Literome

Kawada et al., Cancer Res 2006 (Colorectal Neoplasms...) : In an in vitro study using a human colon cancer cell line, SW480, inhibition of STAT3 by dominant negative STAT3 or the Janus kinase inhibitor, AG490, induced translocation of beta-catenin from the nucleus to the cytoplasm or membrane ... Luciferase assays revealed that STAT3 inhibition resulted in significant suppression of beta-catenin/T-cell factor transcription in association with significant inhibition of cell proliferation ( P < 0.05 ) ... These findings suggest that in colorectal cancer, STAT3 activation is involved in the nuclear accumulation of beta-catenin , resulting in poor patient survival
Yan et al., Cancer Lett 2008 (Carcinoma, Squamous Cell...) : Transfected beta-catenin induced STAT3 transcriptional activity dose-dependently, and also enhanced STAT3 mRNA and protein levels
Wang et al., Hepatogastroenterology 2011 (Carcinoma, Hepatocellular...) : After siRNA directed against STAT3 was transfected into HepG2 cells, STAT3 protein expression was decreased at 72 and 96h and beta-catenin , GSK-3beta and p-GSK-3beta protein expression all increased at 72h and decreased at 96 h after transfection