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CTNNB1 — IGF2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: beta catenin (CTNNB1) → IGF-1R heterotetramer/IGF2 complex (IGF2-IGF1R) (translocation, collaborate)
  Morali et al., Oncogene 2001
  Evidence: physical interaction
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) → IGF-1R heterotetramer/IGF2 complex (IGF2-IGF1R) (translocation, collaborate)
  Morali et al., Oncogene 2001
  Evidence: physical interaction

Text-mined interactions from Literome

Morali et al., Oncogene 2001 : We can show that ( 1 ) IGF-II induces a rapid epithelium to mesenchymal transition ; ( 2 ) IGF1R, the receptor for IGF-II, belongs to the same membrane complex as E-cadherin and beta-catenin ; ( 3 ) IGF-II induces a redistribution of beta-catenin from the plasma membrane to the nucleus and an intracellular sequestration and degradation of E-cadherin ; ( 4 ) IGF-II induces the transcription of beta-catenin/TCF-3 target genes
Chen et al., J Biol Chem 2005 : Functional significance of type 1 insulin-like growth factor mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin
Shanely et al., Am J Physiol Cell Physiol 2009 : Finally, IGF-I increased nuclear beta-catenin protein, and small interfering RNA knockdown of beta-catenin attenuated IGF-I induced 1.3-kb type IIb MyHC promoter activity and type IIb MyHC mRNA